Cu(I)-Catalyzed Intramolecular Hydroamination of Unactivated Alkenes Bearing a Primary or Secondary Amino Group in Alcoholic Solvents
Cu(I)-Catalyzed Intramolecular Hydroamination of Unactivated Alkenes Bearing a Primary or Secondary Amino Group in Alcoholic Solvents
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DOI：
10.1021/ol9007712
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发表时间：
2009-05-21
期刊：
影响因子：
5.2
通讯作者：
Sawamura, Masaya
中科院分区：
文献类型：
--
作者：
Ohmiya, Hirohisa;Moriya, Toshimitsu;Sawamura, Masaya
Cu-Xantphos体系[Cu(O-t-Bu)-Xantphos， 10-15 mol %]在醇溶剂中催化带有无保护氨基烷基取代基的未活化末端烯烃的分子内氢胺化反应，以优异的收率生成吡啶和哌啶衍生物。该体系适用于伯胺和仲胺，并耐受多种官能团。
The Cu-Xantphos system [Cu(O-t-Bu)-Xantphos, 10-15 mol %] catalyzes the intramolecular hydroamination of unactivated terminal alkenes bearing an unprotected aminoalkyl substituent in alcoholic solvents, giving pyrrolidine and piperidine derivatives in excellent yields. This system is applicable to both primary and secondary amines and tolerates a variety of functional groups.