Renin-Angiotensin-Aldosterone System Inhibitors in Patients with Covid-19
Renin-Angiotensin-Aldosterone System Inhibitors in Patients with Covid-19
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DOI：
10.1056/nejmsr2005760
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发表时间：
2020-04-23
影响因子：
158.5
通讯作者：
Solomon, Scott D.
中科院分区：
文献类型：
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作者：
Vaduganathan, Muthiah;Vardeny, Orly;Solomon, Scott D.
肾素-血管紧张素-醛固酮系统阻滞剂对人体血管紧张素转换酶2水平和活性的影响尚不确定。作者假设ACE 2在肺损伤期间可能是有益的而不是有害的，并建议RAAS抑制剂停药可能对一些已知或疑似Covid-19的高风险患者有害。
The effects of renin-angiotensin-aldosterone system blockers on angiotensin-converting enzyme 2 levels and activity in humans are uncertain. The authors hypothesize that ACE2 may be beneficial rather than harmful during lung injury and suggest that RAAS-inhibitor withdrawal may be harmful in some high-risk patients with known or suspected Covid-19.