Suspected allergic reactions after vaccination in 85 dogs in Japan
Suspected allergic reactions after vaccination in 85 dogs in Japan
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DOI：
10.1136/vr.156.3.87
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发表时间：
2005-01-15
影响因子：
2.2
通讯作者：
Tsujimoto, H
中科院分区：
文献类型：
--
作者：
Ohmori, K;Sakaguchi, M;Tsujimoto, H
接种后，在犬中观察到过敏反应，包括速发型过敏反应（布鲁克斯1991，格林1998）。过敏反应是接种疫苗后最严重和危及生命的不良事件。它是由过敏原特异性免疫球蛋白E引起的速发型I型超敏反应的全身性反应，导致肥大细胞和嗜碱性粒细胞释放各种介质（格林1998）。在之前对日本311只接种后出现不良反应的犬进行的回顾性研究中，46只犬出现过敏反应，46例过敏反应中有7例导致死亡（Ohmori等人，2002）。虽然过敏反应，包括过敏反应，接种疫苗后，狗是一个问题，在小动物的做法，很少有人知道他们。本研究旨在获得犬接种疫苗后过敏反应的流行病学信息。2001年1月至2002年7月期间，从日本40名私人小动物兽医从业者处收集了85只在非狂犬病疫苗注射后24小时内出现疑似过敏反应的犬的信息;从每个实践中获得了1至8只犬（平均2· 1只犬）的信息。出于研究目的，疑似过敏反应定义为与I型超敏反应相关的临床体征，如格林（1998）先前描述的接种后发生的肿胀性休克、呼吸困难、面部水肿、瘙痒、虚弱和腹泻。85只犬的信息包括其病史、所用疫苗类型、既往接种史、临床体征和接种后临床体征发生时间;根据其临床体征将犬分为3组。第1组为主要表现为心血管和/或呼吸系统症状的犬，第2组为主要表现为皮肤病症状的犬，第3组为同时表现为心血管/呼吸系统和皮肤病症状的犬。有31只小型腊肠，7只西施犬，6只马耳他犬，6只哈巴狗，4只拉布拉多寻回犬，4只乳头犬，4只约克郡梗，3只小猎犬，3只小型雪纳瑞，3只设得兰群岛牧羊犬，三只玩具贵宾犬，两只吉娃娃，两只金毛寻回犬，两只威尔士矮脚狗和一只秋田犬，一只伯恩山犬和一只博美犬。狗狗的年龄
ALLERGIC reactions, including anaphylaxis, have been observed in dogs after vaccination (Brooks 1991, Greene 1998). Anaphylaxis is the most severe and life-threatening adverse event after vaccination. It is a systemic reaction of immediate type I hypersensitivity caused by allergen-specific immunoglobulin E, which causes the release of various mediators from mast cells and basophils (Greene 1998). In a previous retrospective study of 311 dogs in Japan with adverse reactions after vaccination, 46 of the dogs showed anaphylaxis, and seven of the 46 cases of anaphylaxis resulted in death (Ohmori and others 2002). Although allergic reactions, including anaphylaxis, after vaccination in dogs are a problem in small animal practice, little is known about them. The aim of this study was to obtain epidemiological information regarding allergic reactions after vaccination in dogs. Information on 85 dogs that had showed suspected allergic reactions within 24 hours after non-rabies vaccine injections was collected from 40 private small animal veterinary practitioners in Japan between January 2001 and July 2002; information on one to eight dogs (mean 2· 1 dogs) was obtained from each practice. For the purposes of the study, the suspected allergic reactions were defined as clinical signs associated with type I hypersensitivity, such as hypotensive shock, dyspnoea, facial oedema, pruritus, weakness and diarrhoea, occurring after vaccination, as described previously by Greene (1998). The information on the 85 dogs comprised their history, the types of vaccine used, the history of previous vaccination, the clinical signs, and the time of onset of clinical signs after vaccination; the dogs were classified into three groups based on their clinical signs. Group 1 consisted of dogs with predominantly cardiovascular and/or respiratory signs, group 2 comprised those with predominantly dermatological signs, and group 3 consisted of dogs showing cardiovascular/respiratory and dermatological signs simultaneously.Of the 85 dogs, 83 were purebred and two were crossbred; there were 31 miniature dachshunds, seven shih tzus, six Maltese, six pugs, four labrador retrievers, four papillons, four Yorkshire terriers, three beagles, three miniature schnauzers, three Shetland sheepdogs, three toy poodles, two chihuahuas, two golden retrievers, two Welsh corgis and one akita, one Bernese mountain dog and one pomeranian. The dogs’ ages