Thermodynamic models for determination of the solid-liquid equilibrium of istradefylline in ethyl acetate plus (isopropanol, tetrahydrofuran, acetone) binary solvent mixtures
Thermodynamic models for determination of the solid-liquid equilibrium of istradefylline in ethyl acetate plus (isopropanol, tetrahydrofuran, acetone) binary solvent mixtures
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用于测定伊曲茶碱在乙酸乙酯加（异丙醇、四氢呋喃、丙酮）二元溶剂混合物中固液平衡的热力学模型
DOI：
10.1016/j.jct.2017.03.015
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发表时间：
2017-08
期刊：
影响因子：
--
通讯作者：
Fangfang Shen
中科院分区：
文献类型：
--
作者：
Tianhua Huang;Dingqiang Lu;Xiuquan Ling;Xinxian Wang;Tongqi Liu;Fangfang Shen
在本论文中，我们重点研究了依特瑞芬碱的溶解度和溶液热力学。本文采用重量法研究了依特拉芬茶碱在二元混合溶剂中的溶解度和溶液热力学。在常压下，在278.15 K~333.15 K温度范围内，测定了吲哚茶碱在乙酸乙酯+异丙醇、乙酸乙酯+四氢呋喃和乙酸乙酯+丙酮中的溶解度。采用修正的Apelblat方程、广义共溶解度模型和Jouyban-Acree模型对依特瑞芬的溶解度进行了关联。计算结果表明，修正的Apelblat方程和一般的协溶模型具有较低的平均偏差。由van‘t Hoff方程计算得到的吉布斯能、热焓、热熵等热力学性质的值证明了溶解过程是吸热的。
In this paper, we focused on solubility and solution thermodynamics of istradefylline. Herein, we investigated the solubility and solution thermodynamics of istradefylline in binary solvent mixtures by gravimetric method. The solubility of istradefylline in (ethyl acetate + isopropanol), (ethyl acetate + tetrahydrofuran) and (ethyl acetate + acetone) was measured in the temperature range of 278.15 K– 333.15 K under atmospheric pressure. In order to correlate the solubility of istradefylline, we employed.the modified Apelblat equation, general cosolvency model and Jouyban-Acree model. Computational results showed that the modified Apelblat equation and general cosolvency model have low mean deviation. As calculated by van’t Hoff equation, the values of thermodynamic properties such as Gibbs energy, enthalpy, and entropy proved that the dissolution process is endothermic
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影响因子：
2.6
作者：
Yonghong Hu;Yang Yang-Yang;Cao Yang;Yonglan Li;Wenge Yang;Limin Cheng
通讯作者：
Yonghong Hu;Yang Yang-Yang;Cao Yang;Yonglan Li;Wenge Yang;Limin Cheng
影响因子：
3.8
作者：
Jiang-fan Chen;M. Schwarzschild
通讯作者：
Jiang-fan Chen;M. Schwarzschild
DOI：
10.1016/j.jct.2014.08.012
发表时间：
2015
期刊：
The Journal of Chemical Thermodynamics
影响因子：
--
作者：
Qi Zhang;Yang Yang-Yang;Cuicui Cao;Limin Cheng;Ying Shi;Wenge Yang;Yonghong Hu
通讯作者：
Qi Zhang;Yang Yang-Yang;Cuicui Cao;Limin Cheng;Ying Shi;Wenge Yang;Yonghong Hu
DOI：
10.1016/j.jct.2015.02.002
发表时间：
2015-06
期刊：
The Journal of Chemical Thermodynamics
影响因子：
--
作者：
Qi Zhang;Yang Yang-Yang;Limin Cheng;Cuicui Cao;Zhi-wen Ding;Chunxiao Wang;Wenge Yang;Yonghong Hu;Yonglan Li
通讯作者：
Qi Zhang;Yang Yang-Yang;Limin Cheng;Cuicui Cao;Zhi-wen Ding;Chunxiao Wang;Wenge Yang;Yonghong Hu;Yonglan Li
影响因子：
--
作者：
Ye Qi;Yulong Liu;Jingwei Xie;Minqing Zhang
通讯作者：
Ye Qi;Yulong Liu;Jingwei Xie;Minqing Zhang