Measurement of spin-lattice relaxation times with FLASH for dynamic MRI of the breast
Measurement of spin-lattice relaxation times with FLASH for dynamic MRI of the breast
复制标题
DOI：
10.1259/0007-1285-69-819-206
复制
发表时间：
1996-03-01
影响因子：
2.6
通讯作者：
Murray, AD
中科院分区：
文献类型：
--
作者：
Brookes, JA;Redpath, TW;Murray, AD
使用可变翻转角梯度重聚焦成像技术。在钆对比剂注射前后获得的动态定量 T-1 弛豫图能够计算乳腺组织中顺磁剂的浓度-时间曲线。该成像技术的目的是提高磁共振乳腺X线摄影的诊断准确性。使用校准 T-1 值的模型进行测量，以研究该方法的准确性，特别是由于残余横向磁化强度的不完全破坏和不准确的射频 (RF) 翻转角设置而引起的误差。给出了一个临床例子。该方法对于任何需要快速定量因注射造影剂而导致的体内 T-1 值变化的患者研究都有潜在用途。
Using a variable flip angle gradient refocused imaging technique. dynamic quantitative T-1 relaxation maps acquired before and after the administration of a gadolinium contrast bolus enable the concentration-time curve of the paramagnetic agent in breast tissue to be calculated. This imaging technique has the aim of improving the diagnostic accuracy of MR mammography. Measurements with phantoms of calibrated T-1 values have been carried out to investigate the accuracy of the method, with particular reference to errors caused by incomplete spoiling of residual transverse magnetization and inaccurate radio frequency (RF) flip-angle settings. A clinical example is presented. The method has potential use for any patient study which necessitates rapid quantitation of changing in vivo T-1 values as a result of contrast agent injection.