Cognitive and motor dysfunction in Parkinson's disease. Clinical, performance, and computed tomographic correlations.
Cognitive and motor dysfunction in Parkinson's disease. Clinical, performance, and computed tomographic correlations.
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帕金森病的认知和运动功能障碍。
DOI：
10.1001/archneur.1988.00520320040013
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发表时间：
1988
影响因子：
--
通讯作者：
M. Pollock
中科院分区：
文献类型：
--
作者：
D. Lichter;A. Corbett;G. Fitzgibbon;O. Davidson;J. Hope;G. V. Goddard;K. Sharples;M. Pollock
帕金森氏病（PD）中特异性认知功能障碍与更广泛认知功能障碍的神经病理和病理生理关系尚不完全清楚。在一项对39名PD患者进行的研究中，利用标准化的临床测量、计算机神经心理学测试和定量计算机断层扫描，对这一问题进行了研究。视觉空间辨别障碍和知觉运动功能障碍与运动得分密切相关，提示有共同的神经病理基础。在这种情况下，尾状核和中皮层多巴胺耗竭发挥了作用。与年龄匹配的对照组相比，更广泛的认知功能障碍发生在病程较长、帕金森病更晚期的老年患者中，并且有皮层下和额皮质萎缩的计算机断层扫描证据，但没有明显的脑萎缩。需要进一步的前瞻性临床病理研究来阐明原发性多巴胺能功能障碍、年龄相关变化、阿尔茨海默病型病理状况和其他共存的神经递质缺陷对PD中所见痴呆的相对贡献。
The neuropathologic and pathophysiological relationship of specific to more generalized cognitive dysfunction in Parkinson's disease (PD) remains incompletely understood. This issue was examined in a study of 39 patients with PD, utilizing standardized clinical measures, computerized neuropsychological tests, and quantitative computed tomography. Disorders of visuospatial discrimination and perceptual-motor function closely paralleled motor scores, suggesting a common neuropathologic basis. Caudate nuclear and mesocortical dopamine depletion play a role in this context. More generalized cognitive dysfunction occurred in older patients with a somewhat longer disease duration, more advanced parkinsonism, and computed tomographic evidence of subcortical and frontal cortical atrophy but without significant cerebral atrophy when compared with age-matched controls. Further prospective clinicopathologic studies will be required to clarify the relative contribution of the primary dopaminergic dysfunction, age-related changes, Alzheimer-type pathologic condition, and other coexisting neurotransmitter deficits to the dementia seen in PD.