Epistasis between type 2 diabetes susceptibility loci on chromosomes 1q21-25 and 10q23-26 in northern Europeans
Epistasis between type 2 diabetes susceptibility loci on chromosomes 1q21-25 and 10q23-26 in northern Europeans
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DOI：
10.1111/j.1469-1809.2006.00289.x
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发表时间：
2006-11-01
影响因子：
1.9
通讯作者：
McCarthy, M. I.
中科院分区：
文献类型：
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作者：
Wiltshire, S.;Bell, J. T.;McCarthy, M. I.
易感基因座(上位性)之间相互作用的特征对于全面理解复杂疾病的遗传病因学和分子病理学至关重要。在英国和法国家系中，我们使用两种互补的基于连锁的方法研究了染色体1q21-25和10q23-26上的2型糖尿病易感基因座之间上位性的证据。英国家系中1q和10q的联合两位点连锁分析提供了显著的交互作用证据(P
Characterisation of the interactions between susceptibility loci (epistasis) is central to a full understanding of the genetic aetiology and the molecular pathology of complex diseases. We have examined, in British and French pedigrees, evidence for epistasis between the type 2 diabetes susceptibility loci on chromosomes 1q21-25 and 10q23-26 using two complementary linkage-based approaches. Joint two-locus linkage analysis of 1q and 10q in British pedigrees provided significant evidence for interaction (P