Penicillin is an active-site inhibitor for four genera of bacteria.
Penicillin is an active-site inhibitor for four genera of bacteria.
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青霉素是四种细菌的活性位点抑制剂。
DOI：
10.1128/jb.149.3.1150-1153.1982
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发表时间：
1982
影响因子：
3.2
通讯作者：
Strominger,JL
中科院分区：
文献类型：
--
作者：
Yocum,RR;Amanuma,H;O'Brien,TA;Waxman,DJ;Strominger,JL
通过对细胞壁 D-丙氨酸羧肽酶中青霉素结合位点与底物结合位点进行部分蛋白水解作图的方法，测试了青霉素作为细胞壁生物合成活性位点抑制剂的假设。这种酶是从四个属的细菌中获得的，经过纯化和测试。
The hypothesis that penicillin acts as an active-site inhibitor cell wall biosynthesis was tested by a method of partial proteolytic mapping of penicillin-binding sites versus substrate-binding sites in cell wall D-alanine carboxypeptidases. This enzyme was obtained from four genera of bacteria, purified, and tested.