Fractal dimensions of breast lesions on cytology smears
Fractal dimensions of breast lesions on cytology smears
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DOI：
10.1002/dc.10324
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发表时间：
2003-08-01
影响因子：
1.3
通讯作者：
Mohanty, SK
中科院分区：
文献类型：
--
作者：
Dey, P;Mohanty, SK
本研究对乳腺肿瘤细胞学标本上良恶性细胞的盒维数进行了测量和比较。我们选择了14例经组织病理学证实的浸润性导管癌和7例乳腺纤维腺瘤的细针穿刺细胞学涂片。从每个病例中随机选择5个细胞。借助于图像细胞仪（Leica，剑桥，UK），使用Quantimet 600软件（Leica）测量所有细胞的盒计数分形维数。总共对70例恶性肿瘤细胞和35例良性肿瘤细胞进行了研究。恶性细胞和良性细胞的平均分形维数分别为0.9571 ± 0.1265和0.8354 ± 0.1367。恶性和良性细胞的分形维数差异有统计学意义（P = 0.006，Mann-Whitney非参数检验）。分形维数的测量可能有助于区分恶性和良性细胞。这可能是恶性细胞的另一个区别特征，沿着基于欧几里得几何的经典图像形态测量。
In the present study, box-counting fractal dimensions of benign and malignant cells of breast tumors on cytology material were measured and compared. We selected fine-needle aspiration cytology smears of 14 cases of histopathology-proven infiltrating duct carcinomas and 7 cases of fibroadenoma of the breast. Five cells were randomly selected from each case. Box-counting fractal dimensions of all cells were measured with the help of an image cytometer (Leica, Cambridge, UK), using Quantimet 600 software (Leica). In total. 70 malignant cells and 35 benign cells were studied. The mean fractal dimensions of malignant cells and benign cells were 0.9571 +/- 0.1265 and 0.8354 +/- 0.1367, respectively. There was significant difference in the fractal dimension of malignant and benign cells (P = 0.006, Mann-Whitney nonparametric test). The measurement of fractal dimension may be helpful in discriminating malignant from benign cells. This may be another discriminating feature of malignant cells, along with classic image morphometry based on Euclidean geometry.