Scanning all-fiber-optic endomicroscopy system for 3D nonlinear optical imaging of biological tissues.
Scanning all-fiber-optic endomicroscopy system for 3D nonlinear optical imaging of biological tissues.
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DOI：
10.1364/oe.17.007907
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发表时间：
2009-05-11
期刊：
影响因子：
3.8
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Wu Y;Leng Y;Xi J;Li X
An extremely compact all-fiber-optic scanning endomicroscopy system was developed for two-photon fluorescence (TPF) and second harmonic generation (SHG) imaging of biological samples. A conventional double-clad fiber (DCF) was employed in the endomicroscope for single-mode femtosecond pulse delivery, multimode nonlinear optical signals collection and fast two-dimensional scanning. A single photonic bandgap fiber (PBF) with negative group velocity dispersion at two-photon excitation wavelength (i.e. ~810 nm) was used for pulse prechirping in replacement of a bulky grating/lens-based pulse stretcher. The combined use of DCF and PBF in the endomicroscopy system made the endomicroscope basically a plug-and-play unit. The excellent imaging ability of the extremely compact all-fiber-optic nonlinear optical endomicroscopy system was demonstrated by SHG imaging of rat tail tendon and depth-resolved TPF imaging of epithelial tissues stained with acridine orange. The preliminary results suggested the promising potential of this extremely compact all-fiber-optic endomicroscopy system for real-time assessment of both epithelial and stromal structures in luminal organs.
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影响因子：
3.6
作者：
Liu, XM;Cobb, MJ;Li, XD
通讯作者：
Li, XD
影响因子：
4.4
作者：
Neu, TR;Kuhlicke, U;Lawrence, JR
通讯作者：
Lawrence, JR
影响因子：
3.6
作者：
Myaing, MT;Ye, JY;Russell, PSJ
通讯作者：
Russell, PSJ
影响因子：
2.5
作者：
TREACY, EB
通讯作者：
TREACY, EB
影响因子：
3.6
作者：
CHANG, RL;WANG, JP
通讯作者：
WANG, JP