Point-of-care testing with Xpert HPV for single-visit, screen-and-treat for cervical cancer prevention: a demonstration study in South Africa.
Point-of-care testing with Xpert HPV for single-visit, screen-and-treat for cervical cancer prevention: a demonstration study in South Africa.
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DOI：
10.1038/s41598-023-43467-2
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发表时间：
2023-09-27
影响因子：
4.6
通讯作者：
Kuhn, Louise
中科院分区：
文献类型：
--
作者：
Denny, Lynette;Saidu, Rakiya;Boa, Rosalind;Mbatani, Nomonde;Castor, Delivette;Moodley, Jennifer;Kuhn, Louise
Human papillomavirus (HPV)-based screen-and-treat (SAT) is recommended but implementation presents operational challenges. We implemented HPV-SAT at a research site in Khayelitsha, South Africa, screening 3062 women aged 30–65 years (44% women living with HIV [WHIV]). All were screened using point-of-care Xpert HPV and almost all received their HPV results on the same day. HPV-positivity occurred in 41.5% of WHIV and 17.4% of women without HIV (WNoH) reducing to 26.2% in WHIV and 10.4% in WNoH applying treatment eligibility criteria based on high viral load in the channels detecting HPV16, 18, 45, 16, 18, 31, 33, 35, 52, 58. Among those eligible for treatment, 91.3% were considered suitable for ablative therapy, and 94.6% underwent thermal ablation on the same day, with no serious adverse events. Twelve months later, 39.0% of WHIV and 65.2% of WNoH treated with ablative therapy were clear of HPV. In women who were HPV-positive but ineligible for treatment, 19.1% and 12.9% had histologically-confirmed cervical intraepithelial neoplasia grade 2 or worse (CIN2+) at 12 months. SAT programs need to weigh trade-offs between overtreatment versus delayed or no treatment for women who test positive for HPV. Treatment modalities for precancerous lesions need to be improved.
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影响因子：
6.4
作者：
Zhao, Xue-Lian;Liu, Zhi-Hua;Basu, Partha
通讯作者：
Basu, Partha
影响因子：
3.7
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Singini MG;Sitas F;Bradshaw D;Chen WC;Motlhale M;Kamiza AB;de Villiers CB;Lewis CM;Mathew CG;Waterboer T;Newton R;Muchengeti M;Singh E
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Singh E
DOI：
10.1111/jog.14520
发表时间：
2021-01
期刊：
The journal of obstetrics and gynaecology research
影响因子：
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作者：
Duan L;Du H;Belinson JL;Liu Z;Xiao A;Liu S;Zhao L;Wang C;Qu X;Wu R
通讯作者：
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影响因子：
10.3
作者：
Denny, Lynette;Kuhn, Louise;Wright, Thomas C., Jr.
通讯作者：
Wright, Thomas C., Jr.
影响因子：
4.5
作者：
Slavkovsky RC;Bansil P;Sandoval MA;Figueroa J;Rodriguez DM;Lobo JS;Jeronimo JA;de Sanjosé S
通讯作者：
de Sanjosé S