A multimaterial bioink method for 3D printing tunable, cell-compatible hydrogels.
A multimaterial bioink method for 3D printing tunable, cell-compatible hydrogels.
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DOI：
10.1002/adma.201405076
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发表时间：
2015-03-04
期刊：
影响因子：
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通讯作者：
Shah RN
中科院分区：
文献类型：
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作者：
Rutz AL;Hyland KE;Jakus AE;Burghardt WR;Shah RN
3D生物打印在创建复杂组织和器官模拟以解决移植需求方面显示出巨大的前景，并为药物测试和研究组织形态发生提供平台。然而，缺乏3D打印和细胞兼容的生物墨水以及调整生物墨水材料性能的有限能力被认为是生物打印发展的重要抑制剂。组织工程和生物材料领域的先驱已经建立并验证了材料特性的改变，如刚度[6]、生物活性基团[7][8]和降解[7][9]，会显著影响细胞行为和组织形成。因此，开发新颖、通用和可调的生物链接方法将促进先进材料和结构设计，这将在生物打印和生物制造领域具有重要意义。可用于多种材料的多功能生物墨水合成技术将提高现有生物墨水和大多数生物墨水的可打印性
3D bioprinting shows significant promise for creating complex tissue and organ mimics to solve transplant needs and to provide platforms for drug testing and studying tissue morphogenesis [1][2][3]. However, the lack of 3D printable and cell-compatible bioinks as well as the limited ability to tune bioink material properties are cited as significant inhibitors to the growth of bioprinting [4][5]. Pioneers in the field of tissue engineering and biomaterials have established and validated that changing materials properties such as stiffness [6], bioactive moieties [7][8], and degradation [7][9] significantly impacts cell behavior and tissue formation. Thus, developing novel, versatile and tunable bioink methods that will facilitate advanced material and construct design will have important implications in the field of bioprinting and biofabrication. Versatile bioink synthesis techniques, ones that can be used with many materials, will improve both printability of existing bioinks and most