Establishing a normative atlas of the human lung: Intersubject warping and registration of volumetric CT images
Establishing a normative atlas of the human lung: Intersubject warping and registration of volumetric CT images
复制标题
DOI：
10.1016/s1076-6332(03)80099-5
复制
发表时间：
2003-03-01
影响因子：
4.8
通讯作者：
Reinhardt, JM
中科院分区：
文献类型：
--
作者：
Li, BJ;Christensen, GE;Reinhardt, JM
理由和目标。为了建立肺结构和功能定量CT测量的正常值范围，作者开发了一种方法，用于匹配个体之间的肺结构并创建规范的人类肺图谱。通过三维图像配准，从6名受试者的计算机断层扫描（CT）图像合成了计算机化的人肺图谱。作者为每个CT图像确定了一组可重复的特征点，并使用这些点建立受试者之间的对应关系，使用基于界标和强度的一致性图像配准算法将来自人群的模板图像体积配准到人群中的其余肺部CT体积，平均这些变换，并通过使用平均变换变形模板来构建图谱。通过灰度和分割的CT图像来评估和可视化作者方法的有效性。对于所研究的6个数据集，该方法将平均标志配准误差从10.5 mm降低到0.4 mm，将平均相对体积重叠误差从0.7降低到0.11。该方法和计算机化的人肺图谱构建和可视化的作者用这种方法，提供了一个基础，建立区域范围的正常值的结构和功能的措施，人肺。
Rationale and Objectives. To establish the range of normal values for quantitative CT-based measures of lung structure and function, the authors developed a method for matching pulmonary structures across individuals and creating a normative human lung atlas.Materials and Methods. A computerized human lung atlas was synthesized from computed tomographic (CT) images from six subjects by means of three-dimensional image registration. The authors identified a set of reproducible feature points for each CT image and used these points to establish correspondences across subjects, used a landmark- and intensity-based consistent image registration algorithm to register a template image volume from the population to the rest of the pulmonary CT volumes in the population, averaged these transformations, and constructed an atlas by deforming the template with the average transformation.Results. The effectiveness of the authors' method was evaluated and visualized by means of both gray-level and segmented CT images. The method reduced the average landmark registration error from 10.5 mm to 0.4 mm and the average relative volume overlap error from 0.7 to 0.11 for the six data sets studied.Conclusion. The method, and the computerized human lung atlas constructed and visualized by the authors with this method, provides a basis for establishing regional ranges of normative values for structural and functional measures of the human lung.