Heritability estimation of subcortical volumes in a multi-ethnic multi-site cohort study.
Heritability estimation of subcortical volumes in a multi-ethnic multi-site cohort study.
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多种族多地点队列研究中皮层下体积的遗传力估计。
DOI：
10.1101/2024.01.11.575231
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发表时间：
2024
期刊：
影响因子：
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通讯作者：
Domi
中科院分区：
文献类型：
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作者：
Coffman,Christian;Feczko,Eric;Larsen,Bart;Tervo-Clemmens,Brenden;Conan,Gregory;Lundquist,JacobT;Houghton,Audrey;Moore,LucilleA;Weldon,Kimberly;McCollum,Rae;Perrone,AndersJ;Fayzullobekova,Begim;Madison,ThomasJ;Earl,Eric;Domi
区域皮质下脑容量 (rSBV) 的遗传力描述了遗传学在中脑和内脑发育中的作用。 rSBV 在成人中具有高度遗传性，但在青少年中的特征并不明确。青少年大脑认知发展研究 (ABCD) 在美国 22 个地点进行，提供了描述青春期皮层下结构遗传性的数据。在 ABCD 中，位点特异性效应与遗传效应同时发生，这可能会导致遗传力估计产生偏差。调整场地影响的现有方法需要额外的步骤来调整场地影响，并且可能导致估计不一致。我们提出了一种基于随机效应模型的矩方法，它是单步估计器，即使在站点不平衡的情况下也是理论上一致的估计器，并且在模拟下表现良好。我们比较了 ABCD 中 rSBV 的方法。所提出的方法产生的遗传力估计与之前单中心研究的结果相似。小脑皮质和海马是遗传性最强的区域（> 50%）。
Heritability of regional subcortical brain volumes (rSBVs) describes the role of genetics in middle and inner brain development. rSBVs are highly heritable in adults but are not characterized well in adolescents. The Adolescent Brain Cognitive Development study (ABCD), taken over 22 US sites, provides data to characterize the heritability of subcortical structures in adolescence. In ABCD, site-specific effects co-occur with genetic effects which can bias heritability estimates. Existing methods adjusting for site effects require additional steps to adjust for site effects and can lead to inconsistent estimation. We propose a random-effect model-based method of moments approach that is a single step estimator and is a theoretically consistent estimator even when sites are imbalanced and performs well under simulations. We compare methods on rSBVs from ABCD. The proposed approach yielded heritability estimates similar to previous results derived from single-site studies. The cerebellum cortex and hippocampus were the most heritable regions (> 50%).