Two antagonistic gustatory receptor neurons responding to sweet-salty and bitter taste in Drosophila
Two antagonistic gustatory receptor neurons responding to sweet-salty and bitter taste in Drosophila
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DOI：
10.1002/neu.20063
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发表时间：
2004-12-01
期刊：
影响因子：
--
通讯作者：
Tanimura, T
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文献类型：
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作者：
Hiroi, M;Meunier, N;Tanimura, T
在果蝇中，味觉受体神经元（GRN）存在于被称为感受器的毛发状结构中。大多数味觉感受器都有四种GRN，它们根据对基本刺激的敏感性而命名：水（W细胞），糖（S细胞），低浓度盐（L1细胞）和高浓度盐（L2细胞）。根据其长度和位置，标签味感器可分为1型、s型和i型三种类型。其中，1型和S型的唇瓣感受器拥有这四个细胞，但大多数i型感受器的房子只有两个GRNs。在i型感器，我们在这里证明，第一GRN响应糖和低浓度的盐（10-50 mM NaCl）。第二个GRN检测一系列苦味化合物，其中士的宁是最有效的;以及高浓度的盐（超过400 mM NaCl）。两种类型的GRN都不对水做出反应。在i型感器中的摄食刺激物的检测似乎是由一个GRN与S + LI细胞的组合特性进行的，而另一个GRN以类似于腿上的L2敏感细胞的方式检测摄食抑制剂。因此，这些感受器容纳两个GRN，对行为具有拮抗作用，这表明味觉受体的表达相应地在它们之间分离。(C)2004年，Wiley期刊，hic。
In Drosophila, gustatory receptor neurons (GRNs) occur within hair-like structures called sensilla. Most taste sensilla house four GRNs, which have been named according to their preferred sensitivity to basic stimuli: water (W cell), sugars (S cell), salt at low concentration (L1 cell), and salt at high concentration (L2 cell). Labellar taste sensilla are classified into three types, 1-, s-, and i-type, according to their length and location. Of these, 1- and s-type labellar sensilla possess these four cells, but most i-type sensilla house only two GRNs. In i-type sensilla, we demonstrate here that the first GRN responds to sugar and to low concentrations of salt (10-50 mM NaCl). The second GRN detects a range of bitter compounds, among which strychnine is the most potent; and also to salt at high concentrations (over 400 mM NaCl). Neither type of GRN responds to water. The detection of feeding stimulants in i-type sensilla appears to be performed by one GRN with the combined properties of S + LI cells, while the other GRN detects feeding inhibitors in a similar manner to bitter-sensitive L2 cells on the legs. These sensilla thus house two GRNs having an antagonistic effect on behavior, suggesting that the expression of taste receptors is segregated across them accordingly. (C) 2004 Wiley Periodicals, hic.