Dietary patterns in men and women are simultaneously determinants of altered glucose metabolism and bone metabolism
Dietary patterns in men and women are simultaneously determinants of altered glucose metabolism and bone metabolism
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DOI：
10.1016/j.nutres.2015.12.010
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发表时间：
2016-04-01
影响因子：
4.5
通讯作者：
Kreiger, Nancy
中科院分区：
文献类型：
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作者：
Langsetrno, Lisa;Barr, Susan I.;Kreiger, Nancy
我们假设饮食对加拿大成年人的骨代谢有直接和间接的影响，对葡萄糖代谢有直接影响。我们通过半定量食物频率问卷评估了饮食模式（谨慎[水果，蔬菜，全谷物，鱼和豆类]和西方[软饮料，薯片，炸薯条，肉类和甜点]）。我们使用空腹血液样本测量血糖、胰岛素、稳态模型评估胰岛素抵抗（HOMA-IR）、25-羟基维生素D（25 OHD）、甲状旁腺激素、骨特异性碱性磷酸酶（骨形成标志物）和血清C末端肽（CTX;骨吸收标志物）。我们使用多变量回归模型调整混杂因素，包括/排除体重指数。在二次分析中，我们通过结构方程模型研究了关系。谨慎饮食对葡萄糖代谢（较低的胰岛素和HOMA-IR）和骨代谢（女性较低的CTX;男性较高的25 OHD和较低的甲状旁腺激素）具有有利影响。西方饮食与对葡萄糖代谢（较高的葡萄糖、胰岛素和HOMA-IR）和骨代谢（女性中较高的骨特异性碱性磷酸酶和较低的25 OHD;男性中较高的CTX）的有害影响相关。身体质量指数调整移动点估计向零，表明部分调解。结构方程模型证实了谨慎饮食和西方饮食对代谢风险的强烈影响以及谨慎饮食对骨转换的直接和间接影响的假设联系。总之，谨慎的饮食与较低的代谢风险相关，对骨转换具有主要和介导的影响，这表明它是降低骨折风险的潜在目标。(C)2016 Elsevier Inc. All rights reserved.
We hypothesized that diet would have direct effects on glucose metabolism with direct and indirect effects on bone metabolism in a cohort of Canadian adults. We assessed dietary patterns (Prudent [fruit, vegetables, whole grains, fish, and legumes] and Western [soft drinks, potato chips, French fries, meats, and desserts]) from a semiquantitative food frequency questionnaire. We used fasting blood samples to measure glucose, insulin, homeostatic model assessment insulin resistance (HOMA-IR), 25-hydroxyvitamin D (25OHD), parathyroid hormone, bone-specific alkaline phosphatase (a bone formation marker), and serum C-terminal telopeptide (CTX; a bone resorption marker). We used multivariate regression models adjusted for confounders and including/excluding body mass index. In a secondary analysis, we examined relationships through structural equations models. The Prudent diet was associated with favorable effects on glucose metabolism (lower insulin and HOMA-IR) and bone metabolism (lower CTX in women; higher 25OHD and lower parathyroid hormone in men). The Western diet was associated with deleterious effects on glucose metabolism (higher glucose, insulin, and HOMA-IR) and bone metabolism (higher bone-specific alkaline phosphatase and lower 25OHD in women; higher CTX in men). Body mass index adjustment moved point estimates toward the null, indicating partial mediation. The structural equation model confirmed the hypothesized linkage with strong effects of Prudent and Western diet on metabolic risk, and both direct and indirect effects of a Prudent diet on bone turnover. In summary, a Prudent diet was associated with lower metabolic risk with both primary and mediated effects on bone turnover, suggesting that it is a potential target for reducing fracture risk. (C) 2016 Elsevier Inc. All rights reserved.