FATTY ACID COMPOSITION OF LIVING LAYER AND STRATUM CORNEUM LIPIDS OF HUMAN SOLE SKIN EPIDERMIS
FATTY ACID COMPOSITION OF LIVING LAYER AND STRATUM CORNEUM LIPIDS OF HUMAN SOLE SKIN EPIDERMIS
复制标题
作者：
ANSARI, MNA;NICOLAIDES, N;FU, HC
从人的足底表皮活层和角质层中提取脂类，皂化，并对脂肪酸进行分析。生活层中脂肪酸与不皂化物(主要是胆固醇)的比例高于角质层。人的足底表皮的生活层和角质层的脂肪酸包括饱和脂肪酸、单烯脂肪酸、双烯脂肪酸、微量多烯脂肪酸和α-羟基脂肪酸。生活层和角质层脂肪的单烯和双烯脂肪酸的同系物具有相似的分布。C16和C18是每种酸的主要成分。有两个簇状结构，特别是生活层和角质层酸的饱和物。其中一个从C12到C20，以C16或C18为最大；另一个从C21到C30，以C24为最大。角质层中C20及以上链长的饱和酸所占比例明显高于活体层。生活层和角质层的单烯脂肪酸的位置异构体显示了ω9酸的优势，这是由于油酸的压倒性的大量。到目前为止，亚油酸是二烯酸的主要成分。α-羟基脂肪酸在生活层的同源分布与角质层相似，C20以下和以上的两个酸簇在C16和C24处有最大值。表皮酸和皮脂腺的比较表明，每个组织都可以合成相同种类的酸，但量大不同。棕榈酸和硬脂酸的氧化为角质化的后期阶段提供了必要的能量。
Lipids from the living layer and stratum corneum of human sole epidermis were extracted, saponified and the fatty acids analyzed. The proportion of fatty acids to unsaponifiables (mainly cholesterol), was higher in the living layer than in the stratum corneum. Fatty acids of the living layer and stratum corneum of human sole epidermis comprise saturates, monoenes, dienes, traces of polyenes and α-hydroxy fatty acids. Homologs of monoenoic and dienoic fatty acids for both living layer and stratum corneum lipids have a similar distribution. C16and C18were major components for each type of acids. There appeared to be two clusters, especially for saturates of both living layer and stratum corneum acids. One of these clusters ranged from C12to C20with C16or C18as a maximum and the other ranged from C21to C30with C24as a maximum. The proportion of saturated acids with chain length C20and above was much higher in the stratum corneum than in the living layer. Position isomers of the monoenoic fatty acids for both the living layer and stratum corneum show a predominance of ω9 acids, due to the overwhelmingly large amount of oleic acid. Linoleic acid was by far the major component of the dienoic acids. Homolog distribution of α-hydroxy fatty acids for the living layer was similar to that of the stratum corneum and again two clusters of acids below and above C20with maxima at C16and C24were noticeable. Comparison of epidermal acids with those of sebaceous glands showed that each tissue can synthesize the same kind of acids but in widely different amounts. Oxidation of palmitate and stearate could supply the necessary energy for the late stages of keratinization.