DIRECT PROJECTIONS FROM THE CENTRAL AMYGDALOID NUCLEUS TO THE HYPOTHALAMIC PARAVENTRICULAR NUCLEUS - POSSIBLE ROLE IN STRESS-INDUCED ADRENOCORTICOTROPIN RELEASE
DIRECT PROJECTIONS FROM THE CENTRAL AMYGDALOID NUCLEUS TO THE HYPOTHALAMIC PARAVENTRICULAR NUCLEUS - POSSIBLE ROLE IN STRESS-INDUCED ADRENOCORTICOTROPIN RELEASE
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DOI：
10.1159/000125260
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发表时间：
1989-10-01
影响因子：
4.1
通讯作者：
MAGNUSON, DJ
中科院分区：
文献类型：
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作者：
GRAY, TS;CARNEY, ME;MAGNUSON, DJ
杏仁核，特别是中央杏仁核，在应激过程中对ACTH和皮质酮的反应是重要的。本研究的目的是确定杏仁中央核是否直接支配下丘脑室旁核。为了达到这一目的，采用了菜豆亮氨酸凝集素顺行追踪法。将示踪剂注入杏仁中央内侧核，可在尾侧侧室旁核的内侧和外侧小细胞部分产生轴突和终末标记。在小细胞侧室旁核外侧翼内可见致密的标记斑块。在将凝集素注射定位于中央核外侧部分的动物中，仅在室旁核内观察到少数标记轴突。定位于杏仁内侧核的示踪剂注射导致轴突和终末标记，主要位于下丘脑室旁核的前部、细胞旁和脑室周围区域。在向内侧中央核或内侧核注射示踪剂的动物中，在室旁核的大细胞部分观察到稀疏到中等的轴突和终末标记。在其他杏仁核或纹状体邻近区域注射凝集素的动物的室旁核内没有观察到标记。结果显示从杏仁核到下丘脑室旁核有一个有组织的局部投射。中央核主要支配尾侧、外侧和内侧小细胞侧室旁核。内侧核分布于室旁核的吻侧小细胞部。这些通路可以形成杏仁核调节神经内分泌对应激源反应的解剖基础。
The amygdala, particularly the central amygdaloid nucleus, is important for the expression of ACTH and corticosterone responses during stress. The aim of the present study was to determine if the central amygdaloid nucleus directly innervated the hypothalamic paraventricular nucleus. To accomplish this aim, the Phaseolus vulgaris leucoagglutinin lectin anterograde tracing method was used. Injections of the tracer into the medial central amygdaloid nucleus resulted in axonal and terminal labeling within the medial and lateral parvocellular parts of the caudal paraventricular nucleus. A dense patch of labeling was observed within the lateral wing of the lateral part of the parvocellular paraventricular nucleus. Only a few labeled axons were observed within the paraventricular nucleus of animals that had lectin injections localized to the lateral part of the central nucleus. Tracer injections localized to the medial amygdaloid nucleus resulted in axonal and terminal labeling primarily within the anterior parvocellular and periventricular regions of the paraventricular hypothalamic nucleus. Sparse to moderate axonal and terminal labeling was observed within the magnocellular parts of the paraventricular nucleus in animals that had injections of tracer into either the medial central nucleus or the medial nucleus. No labeling was observed within the paraventricular nucleus of animals that had injections of lectin within other amygdaloid nuclei or adjacent regions of the striatum. The results demonstrated a topographically organized projection from the amygdala to the hypothalamic paraventricular nucleus. The central nucleus mainly innervates the caudal lateral and medial parvocellular paraventricular nucleus. The medial nucleus innervates the rostral parvocellular parts of the paraventricular nucleus. These pathways could form the anatomical substrates of amygdaloid modulation of neuroendocrine responses to stressors.