Lifespan Extension Induced by Caffeine in Caenorhabditis elegans is Partially Dependent on Adenosine Signaling.
Lifespan Extension Induced by Caffeine in Caenorhabditis elegans is Partially Dependent on Adenosine Signaling.
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DOI：
10.3389/fnagi.2015.00220
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发表时间：
2015
影响因子：
4.8
通讯作者：
Romano-Silva MA
中科院分区：
文献类型：
--
作者：
Bridi JC;Barros AG;Sampaio LR;Ferreira JC;Antunes Soares FA;Romano-Silva MA
咖啡因是一种广泛使用的精神活性物质。研究表明，咖啡因可能在与衰老相关的疾病中发挥保护作用。然而，咖啡因调节衰老的机制尚不清楚。在这项研究中，我们已经表明，咖啡因增加秀丽隐杆线虫的寿命，延迟其幼虫发育，减少繁殖和体长。这些表型部分逆转蠕虫的暴露腺苷，这表明一个假定的共同目标。此外，它们依赖于功能性胰岛素/IGF-1样途径。我们的研究结果可能会揭示衰老的新遗传决定因素。
Caffeine is a widely used psychoactive substance. Studies have shown that caffeine may play a protective role in aging-associated disorders. However, the mechanisms by which caffeine modulates aging are not yet clear. In this study, we have shown that caffeine increases Caenorhabditis elegans lifespan, delays its larval development, reduces reproduction and body length. These phenotypes were partly reversed by worm’s exposure to adenosine, which suggest a putative common target. Moreover, they were dependent on a functional insulin/IGF-1-like pathway. Our results may shed light on new genetic determinants of aging.