Impaired endothelial function in coronary heart disease patients with depressive symptomatology
Impaired endothelial function in coronary heart disease patients with depressive symptomatology
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DOI：
10.1016/j.jacc.2005.05.041
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发表时间：
2005-08-16
影响因子：
24
通讯作者：
Blumenthal, JA
中科院分区：
文献类型：
--
作者：
Sherwood, A;Hinderliter, AL;Blumenthal, JA
本研究的目的是评估抑郁症是否与冠心病患者的血管内皮功能障碍有关，在冠心病患者中，抑郁症的存在与死亡风险增加2 - 4倍有关，但涉及的疾病途径尚不确定。内皮功能障碍是冠心病患者心血管事件的危险因素。方法对143例冠心病患者进行肱动脉血流介导的舒张功能（FMD）测定（99名男性，44名女性），年龄40至84岁（平均年龄63 ± 10岁），有冠心病记录。如Beck抑郁量表（BDI）评分>= 10（n = 47）所示，与没有抑郁的患者（BDI < 10; n = 96）相比，FMD减弱（p = 0.001）。抗抑郁药物的使用与FMD的改善相关（p < 0.05）。结论冠心病患者抑郁症状加重，心血管事件风险增加，部分可能是由内皮功能障碍介导的。(c)2005年，美国心脏病学会基金会。
OBJECTIVES The purpose of this study was to assess whether depressive symptomatology was, associated with vascular endothelial dysfunction in patients with coronary heart disease (CHD).BACKGROUND In patients with CHD, the presence of depression is associated with a two to four times increased risk of mortality, but the disease pathways involved are uncertain. Endothelial dysfunction is an established risk factor for cardiovascular events in patient with CHD.METHODS Flow-mediated dilation (FMD) of the brachial artery, it measure of endothelial function, was assessed in 143 patients (99 men, 44 -women), ages 40 to 84 years (mean age, 63 +/- 10 years), with documented CHD.RESULTS Patients with significant depressive symptomatology, as indicated by a Beck Depression Inventory (BDI) score >= 10 (n = 47) showed attenuated FMD (p = 0.001) compared with patients that were not depressed (BDI < 10; n = 96). The use of antidepressant medication was associated with improved FMD (p < 0.05).CONCLUSIONS The increased risk of cardiovascular events in CHD patients with elevated symptoms of depression may be mediated, in part, by endothelial dysfunction. (c) 2005 by the American College of Cardiology Foundation.