Early disturbances in insulin secretion in the development of type 2 diabetes mellitus
Early disturbances in insulin secretion in the development of type 2 diabetes mellitus
复制标题
DOI：
10.1016/s0303-7207(02)00267-8
复制
发表时间：
2002-11-29
影响因子：
4.1
通讯作者：
van Haeften, TW
中科院分区：
文献类型：
--
作者：
van Haeften, TW
在对正常葡萄糖稳态进行简短描述后，描述了三组未来发展为2型糖尿病的高风险人群中胰岛素释放的最新研究结果。葡萄糖耐量受损（IGT）受试者的高血糖钳夹清楚地表明，除了胰岛素敏感性降低外，胰腺β细胞功能也降低。在患有妊娠糖尿病（GDM）的妇女中，胰岛素释放也低于对照组。在葡萄糖耐量正常的高加索一级亲属（FDR）中，各种研究表明β细胞功能低于对照组，而平均胰岛素敏感性正常。这意味着β细胞功能在有患糖尿病风险的受试者中比通常认识到的更早受到干扰。在不久的将来，目前正在进行的遗传学研究可能会揭示2型糖尿病胰岛素分泌和胰岛素作用紊乱的发病机制。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
After a short description of normal glucose homeostasis, recent findings in relation to insulin release in three groups with a high risk of future development of type 2 diabetes are described. Hyperglycemic clamps in subjects with impaired glucose tolerance (IGT) clearly indicate that pancreatic beta cell function is decreased, in addition to the decreased insulin sensitivity. In women with former gestational diabetes mellitus (GDM), insulin release is also lower than in controls. In Caucasian first-degree relatives (FDRs) with normal glucose tolerance, various studies have shown that beta cell function is lower than in controls, while on the average insulin sensitivity is normal. This implies that beta cell function is disturbed earlier in subjects at risk of developing diabetes than is often appreciated. In the near future, the genetic studies currently underway will presumably unravel the pathogenesis of disturbances both in insulin secretion and in insulin action, in type 2 diabetes mellitus. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.