PEG-Based Hydrogel Synthesis via the Photodimerization of Anthracene Groups
PEG-Based Hydrogel Synthesis via the Photodimerization of Anthracene Groups
复制标题
DOI：
10.1021/ma012263z
复制
发表时间：
2002-05
期刊：
影响因子：
5.5
通讯作者：
Yujun Zheng;M. Mićić;Sarita V. Mello;M. Mabrouki;F. Andreopoulos;V. Konka;Si M. Pham;Roger M. Leblanc
中科院分区：
文献类型：
--
作者：
Yujun Zheng;M. Mićić;Sarita V. Mello;M. Mabrouki;F. Andreopoulos;V. Konka;Si M. Pham;Roger M. Leblanc
光交联在生物化学和生物医学领域的智能材料设计中受到了广泛的关注。在这份报告中，我们描述了一种新的光可逆的聚（乙二醇）-（PEG-）为基础的水凝胶系统的合成和性能。9-用蒽甲酸对分子量为20000的八臂聚乙二醇（PEG）进行羟基改性，取代度为87.4%。PEG-蒽大分子单体（PEG-AN）在接近可见光的波长处表现出高光敏性（在366和380 nm处有最大吸收），并且在不存在光引发剂或催化剂的情况下，在暴露于交替波长的照射（365/254 nm）时发生快速和可逆的光交联。光暴露和照射波长的变化可逆地改变了PEG-AN水凝胶的物理化学性质，包括溶胀性、吸收光谱和形貌。
Photo-cross-linking has received a considerable attention for the design of intelligent materials in biochemical and biomedical applications. In this report, we describe the synthesis and properties of a novel photoreversible poly(ethylene glycol)- (PEG-) based hydrogel system. 9-Anthracenecarboxylic acid was used to modify the hydroxyl groups of an eight-armed PEG polymer (molecular weight 20 000) and the degree of substitution was determined to be 87.4%. The PEG−anthracene macromers (PEG−AN) exhibited high photosensitivity at wavelengths close to visible light (absorption maxima at 366 and 380 nm) and underwent rapid and reversible photo-cross-linking upon exposure to alternating wavelengths of irradiation (365/254 nm) in the absence of photoinitiators or catalysts. Changes in light exposure and wavelength of irradiation reversibly altered the physicochemical properties of the PEG−AN hydrogel, including swellability, absorption spectrum, and topography.