Outcome classification of preschool children with autism spectrum disorders using MRI brain measures
Outcome classification of preschool children with autism spectrum disorders using MRI brain measures
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DOI：
10.1097/00004583-200403000-00018
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发表时间：
2004-03-01
影响因子：
13.3
通讯作者：
Courchesne, E
中科院分区：
文献类型：
--
作者：
Akshoomoff, N;Lord, C;Courchesne, E
目的：检验在幼儿期获取的磁共振成像（MRI）脑部测量指标组合能够区分自闭症谱系障碍（ASD）儿童和正常发育儿童，并与功能结局相关这一假设。方法：采用定量MRI技术测量52名初步诊断为自闭症的男孩（年龄1.9 - 5.2岁）和15名正常发育的幼儿（年龄1.7 - 5.2岁）的灰质和白质体积（大脑和小脑）、全脑体积以及小脑蚓部面积。在儿童年满5岁后获取诊断确认和认知结局数据。结果：对MRI脑部测量指标进行的判别函数分析正确分类了95.8%的ASD病例和92.3%的对照病例。这组变量还正确地将85%的ASD病例归类为功能较低，将68%的ASD病例归类为功能较高。结论：这些结果表明，小脑和大脑大小的变异性与患有ASD的幼儿的诊断和功能结局相关。
Objective: To test the hypothesis that a combination of magnetic resonance imaging (MRI) brain measures obtained during early childhood distinguish children with autism spectrum disorders (ASD) from typically developing children and is associated with functional outcome. Method: Quantitative MRI technology was used to measure gray and white matter volumes (cerebrum and cerebellum), total brain volume, and the area of the cerebellar vermis in 52 boys with a provisional diagnosis of autism (aged 1.9-5.2 years) and 15 typically developing young children (aged 1.7-5.2 years). Diagnostic confirmation and cognitive outcome data were obtained after the children reached 5 years of age. Results: A discriminant function analysis of the MRI brain measures correctly classified 95.8% of the ASD cases and 92.3% of the control cases. This set of variables also correctly classified 85% of the ASD cases as lower functioning and 68% of the ASD cases as higher functioning. Conclusions: These results indicate that variability in cerebellar and cerebral size is correlated with diagnostic and functional outcome in very young children with ASD.