Paraventricular Thalamus Projection Neurons Integrate Cortical and Hypothalamic Signals for Cue-Reward Processing
Paraventricular Thalamus Projection Neurons Integrate Cortical and Hypothalamic Signals for Cue-Reward Processing
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DOI：
10.1016/j.neuron.2019.05.018
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发表时间：
2019-08-07
期刊：
影响因子：
16.2
通讯作者：
Stuber, Garret D.
中科院分区：
文献类型：
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作者：
Otis, James M.;Zhu, ManHua;Stuber, Garret D.
室旁丘脑 (PVT) 是大脑奖励回路的接口，输入信号来自前额叶皮层和下丘脑等结构，这些信号被广播到下游边缘目标。然而，PVT 电路用于奖励处理的精确突触连接、活动和功能尚不清楚。在这里，使用体内双光子钙成像，我们发现投射到伏隔核的 PVT 神经元（PVT-NAc）对编码提示奖励关联信息和行为的奖励预测线索产生抑制反应。 PVT-NAc 神经元中的多重活动由前额叶和下丘脑外侧传入轴突中相反的活动模式引导。此外，我们发现前额叶线索编码可以维持准确的线索奖励处理，因为这种编码的光遗传学破坏会对下游 PVT-NAc 线索反应和行为线索辨别产生长期影响。这些数据共同表明，PVT-NAc 神经元通过整合相关输入来准确地告知寻求奖励的行为，从而充当奖励处理的接口。
The paraventricular thalamus (PVT) is an interface for brain reward circuits, with input signals arising from structures, such as prefrontal cortex and hypothalamus, that are broadcast to downstream limbic targets. However, the precise synaptic connectivity, activity, and function of PVT circuitry for reward processing are unclear. Here, using in vivo two-photon calcium imaging, we find that PVT neurons projecting to the nucleus accumbens (PVT-NAc) develop inhibitory responses to reward-predictive cues coding for both cue-reward associative information and behavior. The multiplexed activity in PVT-NAc neurons is directed by opposing activity patterns in prefrontal and lateral hypothalamic afferent axons. Further, we find that prefrontal cue encoding may maintain accurate cue-reward processing, as optogenetic disruption of this encoding induced long-lasting effects on downstream PVT-NAc cue responses and behavioral cue discrimination. Together, these data reveal that PVT-NAc neurons act as an interface for reward processing by integrating relevant inputs to accurately inform reward-seeking behavior.