ACTION POTENTIAL OF MOTOR-NEURON
ACTION POTENTIAL OF MOTOR-NEURON
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DOI：
10.1147/rd.173.0219
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发表时间：
1973-01-01
影响因子：
1.3
通讯作者：
COOLEY, JW
中科院分区：
文献类型：
--
作者：
DODGE, FA;COOLEY, JW
脊髓运动神经元的各个区域的兴奋性可以通过求解神经纤维的偏微分方程来确定，该神经纤维的直径和膜特性随距离而变化。对于我们的模型几何因素的有髓轴突，初始段和细胞体来自解剖测量，树突状树表示其等效圆柱体，和膜的电流-电压关系描述的修改的霍奇金-赫胥黎模型，适合电压钳数据从运动神经元。为了计算出与实验观察相匹配的尖峰波形，1）树突膜必须是不可兴奋的，2）轴突起始段的电压阈值必须比细胞体的电压阈值低10毫伏，3）起始段中的钠电导密度必须比典型的无髓鞘轴突大10倍。
The excitability of various regions of the spinal motorneuron can be specified by solving the partial differential equation of a nerve fiber whose diameter and membrane properties vary with distance. For our model geometrical factors for the myelinated axon, initial segment and cell body were derived from anatomical measurements, the dendritic tree was represented by its equivalent cylinder, and the current-voltage relations of the membrane were described by a modification of the Hodgkin-Huxley model that fits voltage-clamp data from the motorneuron. In order to compute spike waveforms that match experimental observations, 1) the dendritic membrane must be inexcitable, 2) the voltage threshold of the initial segment of the axon must be ten millivolts lower than that of the cell body, and 3) the density of sodium conductance in the initial segment must be ten times greater than in a typical unmyelinated axon.