Role of the yeast Snf1 protein kinase in invasive growth
Role of the yeast Snf1 protein kinase in invasive growth
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DOI：
10.1042/bst0310175
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发表时间：
2003-02-01
影响因子：
3.9
通讯作者：
Carlson, M
中科院分区：
文献类型：
--
作者：
Kuchin, S;Vyas, VK;Carlson, M
酿酒酵母的蔗糖非发酵蛋白激酶1（Snf1）在葡萄糖限制的转录、代谢和发育反应中起重要作用。在这里，我们讨论的Snf1激酶在调节丝状侵入性生长的作用。单倍体侵入性生长发生在响应葡萄糖限制，并需要FLO11，编码细胞表面粘附素的基因。Snf1通过拮抗两个阻遏物Nrg 1和Nrg 2的功能来调节FLO11的转录。Snf1和Nrg阻遏物也影响二倍体假菌丝分化，这是对氮限制的响应，表明Snf1激酶具有意想不到的信号作用。
The sucrose non-fermenting 1 (Snf1) protein kinase of Saccharomyces cerevisiae is important for transcriptional, metabolic and developmental responses to glucose limitation. Here we discuss the role of the Snf1 kinase in regulating filamentous invasive growth. Haploid invasive growth occurs in response to glucose limitation and requires FLO11, a gene encoding a cell-surface adhesin. Snf1 regulates transcription of FLO11 by antagonizing the function of two repressors, Nrg1 and Nrg2. Snf1 and the Nrg repressors also affect diploid pseudohyphal differentiation, which is a response to nitrogen limitation, suggesting an unexpected signalling role for the Snf1 kinase.