Thermoplastic elastomer gels: an advanced substrate for microfluidic chemical analysis systems.
Thermoplastic elastomer gels: an advanced substrate for microfluidic chemical analysis systems.
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DOI：
10.1021/ac050448o
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发表时间：
2005-06
影响因子：
7.4
通讯作者：
A. Sudarsan;Jian Wang;V. Ugaz
中科院分区：
文献类型：
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作者：
A. Sudarsan;Jian Wang;V. Ugaz
我们展示了热塑性弹性体凝胶作为先进基材的用途，用于构建适用于小型化化学分析系统的复杂微流体网络。这些凝胶是通过将廉价的聚苯乙烯-(聚乙烯/聚丁烯)-聚苯乙烯三嵌段共聚物与乙烯/丁烯中间嵌段选择性混溶的烃增量油组合而合成的。不溶性苯乙烯末端嵌段相分离成局部纳米域，从而形成光学透明、粘弹性和生物相容性的凝胶网络，该凝胶网络可在 100 摄氏度左右的温度下熔融加工。这种独特的性能组合允许通过简单地在加热的母模上制作负浮雕结构的印模，在几分钟内制造出微流体通道。熔融加工性允许针对不同的母版制作多个印模，以构建在同一微通道内包含多高度特征的复杂几何形状。由于能够通过短暂加热粘合界面处的材料来粘合和密封多层，因此也可以轻松制造复杂的互连多层结构。通过适当选择凝胶成分，可以在很宽的范围内调节热性能和机械性能。
We demonstrate the use of thermoplastic elastomer gels as advanced substrates for construction of complex microfluidic networks suitable for use in miniaturized chemical analysis systems. These gels are synthesized by combining inexpensive polystyrene-(polyethylene/polybutylene)-polystyrene triblock copolymers with a hydrocarbon extender oil for which the ethylene/butylene midblocks are selectively miscible. The insoluble styrene end blocks phase separate into localized nanodomains, resulting in the formation of an optically transparent, viscoelastic, and biocompatible gel network that is melt-processable at temperatures in the vicinity of 100 degrees C. This unique combination of properties allows microfluidic channels to be fabricated in a matter of minutes by simply making impressions of the negative relief structures on heated master molds. Melt processability allows multiple impressions to be made against different masters to construct complex geometries incorporating multi-height features within the same microchannel. Intricate interconnected multilayered structures are also easily fabricated owing to the ability to bond and seal multiple layers by briefly heating the material at the bond interface. Thermal and mechanical properties are tunable over a wide range through proper selection of gel composition.