CORRELATION BETWEEN AGE-RELATED CHANGES IN OPEN FIELD BEHAVIOR AND PLAQUE FORMING CELL RESPONSE IN DA FEMALE RATS
CORRELATION BETWEEN AGE-RELATED CHANGES IN OPEN FIELD BEHAVIOR AND PLAQUE FORMING CELL RESPONSE IN DA FEMALE RATS
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DA 雌性大鼠中年龄相关的开放行为变化与斑块形成细胞反应之间的相关性
DOI：
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发表时间：
2003
影响因子：
2.2
通讯作者：
J. Radulovic
中科院分区：
文献类型：
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作者：
C. Todorovic;M. Dimitrijević;S. Stanojević;V. Kovačević‐Jovanović;T. Miletić;O. Laban;J. Radulovic
We investigated the relationship between immunological and behavioral changes during ageing in Dark Agouti female rats. Results showed that ageing was associated with decreased exploratory behavior and increased emotionality (open field test) and decreased pain perception (writhing assay), but not with altered depression-like behavior (forced swim test). The observed behavioral changes were paralleled with decreased innate immunity in middle-aged and old rats, as revealed by reduced peroxide production of peritoneal macrophages; and decreased specific immunity, measured by the plaque-forming cell response, in old rats in comparison with young rats. Correlation analyses between behavioral and immune parameters demonstrated a significant correlation between the lines crossed in the open field test and the plaque-forming cell response. Taken together, the demonstrated age-dependent association between exploratory behavior and specific immune response suggests a senescent decline of a common neuroimmune regulatory mechanism.
18 个月大的大鼠中，TNF-α 和 PGI(2) 增加，但巨噬细胞释放的 NO 没有增加。
影响因子：
5.3
作者：
Tang,Y;DiPietro,L;Feng,Y;Wang,X
通讯作者：
Wang,X
中枢促肾上腺皮质激素释放激素激活交感神经系统并降低免疫功能：老年大鼠的反应性增加。
影响因子：
4.8
作者：
Irwin,M;Hauger,R;Brown,M
通讯作者：
Brown,M
β-肾上腺素受体阻断改变老年小鼠的胸腺细胞分化。
DOI：
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发表时间：
2001
期刊：
Cellular and molecular biology (Noisy-le-Grand, France)
影响因子：
--
作者：
Madden,KS;Felten,DL
通讯作者：
Felten,DL