Polydopamine-based surface modification of mesoporous silica nanoparticles as pH-sensitive drug delivery vehicles for cancer therapy
Polydopamine-based surface modification of mesoporous silica nanoparticles as pH-sensitive drug delivery vehicles for cancer therapy
复制标题
基于聚多巴胺的介孔二氧化硅纳米颗粒表面改性作为癌症治疗的 pH 敏感药物输送载体。
DOI：
10.1016/j.jcis.2015.11.001
复制
发表时间：
2016-02-01
影响因子：
9.9
通讯作者：
Zeng, Xiaowei
中科院分区：
文献类型：
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作者：
Chang, Danfeng;Gao, Yongfeng;Zeng, Xiaowei
以聚多巴胺（PDA）修饰介孔二氧化硅纳米粒（MSNs）为载体，制备了一种pH敏感的新型药物缓释系统，用于阳离子两亲药物地昔帕明（DES）的控释。对MSNs-DES-PDA的粒径、粒径分布、表面形貌、BET比表面积、介孔尺寸和孔容、载药量和体外释药特性进行了表征。MSNs-DES-PDA具有较高的载药量和pH敏感性。MSNsDES和MSNs-DES-PDA的DES释放曲线完全不同，MSNs-DES-PDA的药物释放随酸度的增加而加速。MSNs-DES-PDA可以内化到细胞中。体外实验表明，MSNs-DES-PDA对酸性鞘磷脂酶的抑制作用和细胞毒性均高于游离DES。该给药系统有利于药物的控制释放和肿瘤的治疗。(C)2015 Elsevier Inc. All rights reserved.
A novel pH-sensitive drug delivery system of mesoporous silica nanoparticles (MSNs) which were modified by polydopamine (PDA) for controlled release of cationic amphiphilic drug desipramine (DES) was prepared. MSNs-DES-PDA were characterized in terms of size, size distribution, surface morphology, BET surface area, mesoporous size and pore volume, drug loading content and in vitro drug release profile. MSNs-DES-PDA had high drug loading content and pH sensitivity. The DES release profiles of MSNsDES and MSNs-DES-PDA were totally different, and the drug release of MSNs-DES-PDA accelerated with increasing acidity. MSNs-DES-PDA can be internalized into cells. In vitro experiments demonstrated that MSNs-DES-PDA had higher cytotoxicity and inhibitory effects on acid sphingomyelinase than those of free DES. This drug delivery system was beneficial for controlled release and cancer therapy. (C) 2015 Elsevier Inc. All rights reserved.