Association between high expression macrophage migration inhibitory factor (MIF) alleles and West Nile virus encephalitis
Association between high expression macrophage migration inhibitory factor (MIF) alleles and West Nile virus encephalitis
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DOI：
10.1016/j.cyto.2015.11.021
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发表时间：
2016-02-01
期刊：
影响因子：
3.8
通讯作者：
Bucala, Richard
中科院分区：
文献类型：
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作者：
Das, Rituparna;Loughran, Kerry;Bucala, Richard
蚊子传播的西尼罗河病毒（WNV）感染通常无症状，但可导致严重的西尼罗河病毒脑炎。在动物模型中，先天细胞因子巨噬细胞迁移抑制因子（MIF）在西尼罗河病毒脑炎患者中升高，并促进病毒神经侵袭和死亡率。在一项病例对照研究中，我们在454名北美神经侵袭性西尼罗河病毒疾病患者队列中检测了MIF基因座的功能多态性，发现高表达MIF等位基因纯合的患者患西尼罗河病毒脑炎的可能性要高20倍（p = 0.008）。这些数据表明，MIF是西尼罗河病毒神经发病严重程度的重要决定因素，可能是一种治疗靶点。(C) 2015 Elsevier Ltd.版权所有。
Infection with mosquito-borne West Nile virus (WNV) is usually asymptomatic but can lead to severe WNV encephalitis. The innate cytokine, macrophage migration inhibitory factor (MIF), is elevated in patients with WNV encephalitis and promotes viral neuroinvasion and mortality in animal models. In a case-control study, we examined functional polymorphisms in the MIF locus in a cohort of 454 North American patients with neuroinvasive WNV disease and found patients homozygous for high-expression MIF alleles to be >20-fold (p = 0.008) more likely to have WNV encephalitis. These data indicate that MIF is an important determinant of severity of WNV neuropathogenesis and may be a therapeutic target. (C) 2015 Elsevier Ltd. All rights reserved.