THE INFLUENCE OF STRAIN ON ACUTE X-RAY LETHALITY IN THE MOUSE .1. LD50 AND DEATH RATE STUDIES
THE INFLUENCE OF STRAIN ON ACUTE X-RAY LETHALITY IN THE MOUSE .1. LD50 AND DEATH RATE STUDIES
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DOI：
10.2307/3570420
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发表时间：
1956-01-01
影响因子：
3.4
通讯作者：
KALLMAN, RF
中科院分区：
文献类型：
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作者：
KOHN, HI;KALLMAN, RF
用X射线（250 kvcp，HVL 1.6 mm Cu，单次全身暴露，组织剂量率[图像]35 r/min）照射4个近交系的成年小鼠（91至231天）和其中2个的杂交小鼠。LD 50（19）与LD 50（28）几乎相同。雌性可能比雄性稍有抵抗力，但不超过LD 50的4%。分析存活数据的菌株差异。所有菌株的概率单位转换剂量-效应（杀灭）曲线的斜率函数相同。不同品系的LD_（50）（28）分别为：C_3H，665 r; A/He，632 r; C_57BL，618 r; BALB/c，544 r。将BALB/c和A/He品系杂交，得到了LD 50为650 r.提示BALB/c品系LD_（50）较低是隐性遗传因素的表现。当剂量低于LD_（100）时，A/He、BALB/c、CAF_1和C_（3 H）株的死亡率曲线在照射后12-15天出现一个单峰。对于C57 BL株，在辐射后3-20天的间隔期间的死亡率相对恒定，尽管有2个小峰的迹象。
Adult mice (91 to 231 days old) of 4 inbred strains and the hybrid of 2 of them were irradiated with X-rays (250 kvcp, HVL 1.6 mm Cu, single whole-body exposure, tissue dose rate[image]35 r/ minute. The LD50(19) was practically the same as the LD50(28). Females may have been slightly more resistant than males, but not by more than 4% of the LD50. Survival data were analyzed for strain differences. The slope function of the probit-transformed dose-effect (killing) curve was the same for all strains. The LD50(28) determinations for the different strains were: C3H, 665 r; A/He, 632 r; C57BL, 618 r; BALB/c, 544 r. Crossing the BALB/c and A/He strains gave F1 progeny (CAF1) with an LD50 of [image] 650 r. It was suggested that the lower LD50 of the BALB/c strain was an expression of recessive genetic factors. For doses below the LD100 the death-rate curves of the A/He, BALB/c, CAF1, and C3H strains had a single prominent peak during the interval 12-15 days postirradiation. For the C57BL strain, the death rate during the interval 3-20 days postirradiation was relatively constant, although with indications of 2 minor peaks.