Effect of olmesartan on oxidative stress in hemodialysis patients
Effect of olmesartan on oxidative stress in hemodialysis patients
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DOI：
10.1291/hypres.30.395
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发表时间：
2007-05-01
影响因子：
5.4
通讯作者：
Otagiri, Masaki
中科院分区：
文献类型：
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作者：
Kadowaki, Daisuke;Anraku, Makoto;Otagiri, Masaki
奥美沙坦是一种血管紧张素II 1型受体拮抗剂（ARB），其对血液透析（HD）患者氧化应激的影响尚未完全明确，且在体外和体内都未得到广泛研究。在一项体外研究中，我们通过高效液相色谱法（HPLC）以及亚铁氧化二甲酚试验，测定了在有奥美沙坦和无奥美沙坦存在的情况下孵育过程中形成的氧化白蛋白和白蛋白过氧化氢的量。6名高血压血液透析患者每日接受一次40mg奥美沙坦治疗，并在治疗0周、4周和8周后进行血压监测（BPM）。同时还测定了氧化与未氧化白蛋白的比例。与无奥美沙坦存在的情况相比，有奥美沙坦存在时，氧化白蛋白的比例以及白蛋白过氧化氢的水平以浓度依赖的方式显著降低（p
The effect of olmesartan, an inverse angiotensin II type 1 receptor blocker (ARB), on oxidative stress in hemodialysis (HD) patients is not fully understood, and has not been widely investigated in vitro or in vivo. We determined the amount of oxidized albumin and albumin hydroperoxides formed during incubation in the absence and presence of olmesartan by high-performance liquid chromatography (HPLC) and by a ferrous oxidation xylenol assay in an in vitro study. Six hypertensive HD patients were treated with 40 mg of olmesartan once daily, and blood pressure monitoring (BPM) was performed after 0, 4, and 8 weeks of treatment. The ratio of oxidized to unoxidized albumin was also determined. The oxidized albumin ratios and levels of albumin hydroperoxides were significantly decreased in a concentration-dependent manner in the presence of olmesartan, compared with the absence of olmesartan (p