Regional atrial blood flow in dogs. Effect of hypertrophy on coronary flow reserve.
Regional atrial blood flow in dogs. Effect of hypertrophy on coronary flow reserve.
复制标题
狗的局部心房血流。
DOI：
10.1172/jci114053
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
GreenfieldJr,JC
中科院分区：
文献类型：
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作者：
Bauman,RP;Rembert,JC;GreenfieldJr,JC
关于正常和肥厚心房在不同血流动力学状态下的局部心房血流反应知之甚少。本研究旨在建立慢性心房肥大犬模型，并确定该组和正常犬对急性心房颤动的局部血流反应，并测量冠状动脉血流储备。在12只心房肥厚而心室无肥厚的犬中，左、右心房重量平均值分别比正常组高75%和47%。在正常犬的两个心房的血流在附件比在非附件区少，并在心房颤动时显着增加。在肥大组中观察到类似的发现，除了在对照条件下左心耳血流与非心耳血流相似。与正常组28 +/- 2 mmHg/cm 3/min/g相比，肥大组的最小血管阻力39 +/- 3显著（P <0.05）更大。因此，在正常和肥厚的心房中均出现显著的局部血流差异。此外，心房肥大不会改变房颤血流动力学应激的自动调节能力，但会降低冠状动脉血流储备。图片
Little is known regarding regional atrial blood flow responses during varying hemodynamic states in both the normal and hypertrophied atria. This study was undertaken to develop a canine model of chronic atrial hypertrophy and to define in both this group and in normal dogs the regional blood flow response to acute atrial fibrillation and to measure coronary flow reserve. In the 12 dogs with atrial but not ventricular hypertrophy the mean left and right atrial weights were 75 and 47% respectively greater than in the normal group. Blood flow in the normal dogs was less in the appendage than in the non-appendage region for both atria and increased significantly during atrial fibrillation. Similar findings were noted in the hypertrophy group except that during control conditions the left atrial appendage flow was similar to the nonappendage flow. Minimal vascular resistance for the hypertrophy group, 39 +/- 3 was significantly (P less than 0.05) greater when compared to the normal group 28 +/- 2 mmHg/cm3 per min per g. Thus, significant regional blood flow differences occur in both the normal and hypertrophied atria. In addition, atrial hypertrophy does not alter the autoregulatory capacity to the hemodynamic stress of atrial fibrillation but does reduce coronary flow reserve.Images
DOI：
--
发表时间：
1962
期刊：
影响因子：
--
作者：
M. Williams
通讯作者：
M. Williams