Computational and experimental models of cancer cell response to fluid shear stress.
Computational and experimental models of cancer cell response to fluid shear stress.
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DOI：
10.3389/fonc.2013.00044
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发表时间：
2013
影响因子：
4.7
通讯作者：
King MR
中科院分区：
文献类型：
--
作者：
Mitchell MJ;King MR
很明显，机械力在癌症转移中起着关键作用，这是一系列复杂的步骤，导致了大多数与癌症相关的死亡。其中一种力是流体剪切力，它通过血管微环境中的血液流动作用于循环中的肿瘤细胞，也作用于暴露在肿瘤微环境中缓慢的间质流动中的肿瘤细胞。计算和实验模型有可能阐明暴露在这种力下的细胞的转移行为。在这里，我们回顾了肿瘤细胞暴露在血管和肿瘤微环境中的流体作用力，并讨论了最近的计算和实验模型，这些模型揭示了可能在转移过程中发挥作用的机械转导现象。
It has become evident that mechanical forces play a key role in cancer metastasis, a complex series of steps that is responsible for the majority of cancer-related deaths. One such force is fluid shear stress, exerted on circulating tumor cells by blood flow in the vascular microenvironment, and also on tumor cells exposed to slow interstitial flows in the tumor microenvironment. Computational and experimental models have the potential to elucidate metastatic behavior of cells exposed to such forces. Here, we review the fluid-generated forces that tumor cells are exposed to in the vascular and tumor microenvironments, and discuss recent computational and experimental models that have revealed mechanotransduction phenomena that may play a role in the metastatic process.