Abdominal magnetic resonance imaging in small rodents using a clinical 1.5 T MR scanner
Abdominal magnetic resonance imaging in small rodents using a clinical 1.5 T MR scanner
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DOI：
10.1016/j.ymeth.2007.03.010
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发表时间：
2007-09-01
期刊：
影响因子：
4.8
通讯作者：
Candinas, Daniel
中科院分区：
文献类型：
--
作者：
Inderbitzin, Daniel;Stoupis, Christoforos;Candinas, Daniel
由于与其他成像技术相比具有卓越的软组织对比度，非侵入性腹部磁共振成像 (MRI) 非常适合监测各种实验动物模型的器官再生、组织修复、癌症阶段和治疗效果。目前，复杂的 MR 协议，包括技术要求较高的运动伪影补偿程序，在理想条件下可实现 < 100 μm 的 MRI 分辨率极限。然而，大多数实验啮齿动物研究并不需要如此高的空间分辨率。本文介绍了在普遍存在的市售 1.5 T MR 装置中采集 MR 数据的详细成像协议以及器官、组织成分或肿瘤的 3 维体积测定。 MR技术的未来发展将允许在细胞甚至分子水平上对生理和病理过程进行体内研究。实验 MRI 对于广泛的生物过程的无创监测至关重要，并将进一步加深我们对生理学和疾病的一般理解。 (c) 2007 Elsevier Inc. 保留所有权利。
Because of superior soft-tissue contrast compared to other imaging techniques, non-invasive abdominal magnetic resonance imaging (MRI) is ideal for monitoring organ regeneration, tissue repair, cancer stage, and treatment effects in a wide variety of experimental animal models. Currently, sophisticated MR protocols, including technically demanding procedures for motion artefact compensation, achieve an MRI resolution limit of < 100 mu m under ideal conditions. However, such a high spatial resolution is not required for most experimental rodent studies. This article describes both a detailed imaging protocol for MR data acquisition in a ubiquitously and commercially available 1.5 T MR unit and 3-dimensional volumetry of organs, tissue components, or tumors. Future developments in MR technology will allow in vivo investigation of physiological and pathological processes at the cellular and even the molecular levels. Experimental MRI is crucial for non-invasive monitoring of a broad range of biological processes and will further our general understanding of physiology and disease. (c) 2007 Elsevier Inc. All rights reserved.