Autophagy and the Cell Cycle: A Complex Landscape.
Autophagy and the Cell Cycle: A Complex Landscape.
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DOI：
10.3389/fonc.2017.00051
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发表时间：
2017
影响因子：
4.7
通讯作者：
Cecconi F
中科院分区：
文献类型：
--
作者：
Mathiassen SG;De Zio D;Cecconi F
自噬是一种自降解途径，其中细胞质物质被隔离在双膜囊泡中并被递送到溶酶体进行降解。在基础条件下，自噬起着自我平衡的作用。然而，响应于各种应激，该途径可以被进一步诱导以介导细胞保护。缺陷性自噬与许多人类病理学有关，包括肿瘤转化，尽管自噬在某些情况下也可以维持肿瘤细胞的生长。近年来，自噬诱导和应激相关的细胞周期反应之间出现了相当大的相关性，以及自噬因子和选择性自噬降解在细胞分裂过程中的意想不到的作用。这些进展对我们理解自噬和癌症之间的复杂关系具有明显的意义。在这篇综述中，我们将讨论我们目前的知识相互调节连接的自噬途径和细胞周期进程。此外，涉及细胞周期调控中自噬相关因子的非自噬功能的关键发现将得到解决。
Autophagy is a self-degradation pathway, in which cytoplasmic material is sequestered in double-membrane vesicles and delivered to the lysosome for degradation. Under basal conditions, autophagy plays a homeostatic function. However, in response to various stresses, the pathway can be further induced to mediate cytoprotection. Defective autophagy has been linked to a number of human pathologies, including neoplastic transformation, even though autophagy can also sustain the growth of tumor cells in certain contexts. In recent years, a considerable correlation has emerged between autophagy induction and stress-related cell-cycle responses, as well as unexpected roles for autophagy factors and selective autophagic degradation in the process of cell division. These advances have obvious implications for our understanding of the intricate relationship between autophagy and cancer. In this review, we will discuss our current knowledge of the reciprocal regulation connecting the autophagy pathway and cell-cycle progression. Furthermore, key findings involving nonautophagic functions for autophagy-related factors in cell-cycle regulation will be addressed.