Novel quinazoline-quinoline alkaloids with cytotoxic and DNA topoisomerase II inhibitory activities
Novel quinazoline-quinoline alkaloids with cytotoxic and DNA topoisomerase II inhibitory activities
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DOI：
10.1016/j.bmcl.2003.12.048
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发表时间：
2004-03-08
影响因子：
2.7
通讯作者：
Chen, YJ
中科院分区：
文献类型：
--
作者：
Ma, ZZ;Hano, YS;Chen, YJ
合成了两个新的洛托宁A和F类似物7-乙酰氨基洛托宁A（6）和3-[3 H（喹唑啉-4-酮）]喹啉（7）。新的类似物，沿着四种天然喹唑啉-喹啉生物碱，luotonins A（1）、B（2）、E（3）、F（4）和合成的deoxoluotonin F（5），在25 μ M的浓度下显示出细胞毒性活性（IC 50 1.8-40.0 μ g/mL）和DNA拓扑异构酶II抑制。(C)2003 Elsevier Ltd.保留所有权利。
Two new synthetic analogues of luotonins A and F, 7-acetylaminoluotonin A (6) and 3-[3H(quinazolino-4-one)]quinoline (7) were synthesized. The new analogues, along with four natural quinazoline-quinoline alkaloids, luotonins A (1), B (2), E (3), F (4) and a synthetic deoxoluotonin F (5), showed cytotoxic activity (IC50 1.8-40.0 mug/mL) and DNA topoisomerase II inhibition at a concentration of 25 muM. (C) 2003 Elsevier Ltd. All rights reserved.