Temporally Diverse Excitation Generates Direction- Selective Responses in ON- and OFF-Type Retinal Starburst Amacrine Cells
Temporally Diverse Excitation Generates Direction- Selective Responses in ON- and OFF-Type Retinal Starburst Amacrine Cells
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DOI：
10.1016/j.celrep.2017.01.026
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发表时间：
2017-02-07
期刊：
影响因子：
8.8
通讯作者：
Borghuis, Bart G.
中科院分区：
文献类型：
--
作者：
Fransen, James W.;Borghuis, Bart G.
感觉感受野的复杂性从一个突触阶段到下一个突触阶段增加。在许多情况下，增加的复杂性是通过会聚兴奋性和抑制性输入之间的时空相互作用来实现的。在这里，我们提出的证据表明，方向选择性（DS），视网膜星爆无长突细胞（SAC）的一个复杂的紧急感受野属性，是由功能不同的兴奋性输入之间的时空相互作用产生的。来自ON和OFF SAC的电生理全细胞记录显示出近端与远端刺激其感受野后兴奋的明显时间差异。远端兴奋既快又短暂，排除了树突的被动过滤，表明任务特异性专业化。模型模拟表明，这种特定的激励组织产生强大的DS响应在SAC，与基本的运动检测器模型一致。这些结果表明，时空模式化的激励的选择性整合是在哺乳动物视网膜运动检测的计算机制。
The complexity of sensory receptive fields increases from one synaptic stage to the next. In many cases, increased complexity is achieved through spatio-temporal interactions between convergent excitatory and inhibitory inputs. Here, we present evidence that direction selectivity (DS), a complex emergent receptive field property of retinal starburst amacrine cells (SACs), is generated by spatio-temporal interactions between functionally diverse excitatory inputs. Electrophysiological whole- cell recordings from ON and OFF SACs show distinct temporal differences in excitation following proximal compared with distal stimulation of their receptive fields. Distal excitation is both faster and more transient, ruling out passive filtering by the dendrites and indicating a task- specific specialization. Model simulations demonstrate that this specific organization of excitation generates robust DS responses in SACs, consistent with elementary motion detector models. These results indicate that selective integration of spatiotemporally patterned excitation is a computational mechanism for motion detection in the mammalian retina.