Neuroanatomical correlates of externally and internally generated human emotion.
Neuroanatomical correlates of externally and internally generated human emotion.
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人类外部和内部产生的情绪的神经解剖学关联。
DOI：
10.1176/ajp.154.7.918
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Chen,K
中科院分区：
文献类型：
--
作者：
Reiman,EM;Lane,RD;Ahern,GL;Schwartz,GE;Davidson,RJ;Friston,KJ;Yun,LS;Chen,K
目的应用正电子发射断层扫描技术研究正常人类情绪的神经基础及其对情绪刺激类型的依赖。方法12名健康女性受试者在静脉注射[15O]H2O后，在情绪产生和控制、电影和回忆任务之间交替时，进行了12项脑区活动的测量。自动图像分析技术被用来表征和比较与复杂的视觉(电影)和认知(回忆)刺激的情绪反应相关的区域大脑活动的增加。结果电影和回忆产生的情绪都与内侧前额叶皮质和丘脑附近的活动显著增加相关，这表明这些区域参与的情绪方面与情绪刺激的性质无关。电影产生的情绪与两侧枕颞顶叶皮质、外侧小脑、下丘脑以及包括前颞叶皮质、杏仁核和海马结构在内的区域的活动显著增加有关，这表明这些区域参与了对某些外部感官刺激的情绪反应。回忆产生的悲伤与前岛叶皮质附近的活动显著增加有关，这表明该区域参与了对潜在的痛苦认知或内感感觉刺激的情绪反应。结论虽然这项研究应该被认为是初步的，但它确定了参与外部和内部产生的人类情绪的大脑区域。
ObjectivePositron emission tomography was used to investigate the neural substrates of normal human emotional and their dependence on the types of emotional stimulus.MethodTwelve healthy female subjects underwent 12 measurements of regional brain activity following the intravenous bolus administration of [15O] H2O as they alternated between emotion-generating and control film and recall tasks. Automated image analysis techniques were used to characterize and compare the increases in regional brain activity associated with the emotional response to complex visual (film) and cognitive (recall) stimuli.ResultsFilm-and recall-generated emotion were each associated with significantly increased activity in the vicinity of the medial prefrontal cortex and thalamus, suggesting that these regions participate in aspects of emotion that do not depend on the nature of the emotional stimulus. Film-generated emotion was associated with significantly greater increases in activity bilaterally in the occipitotemporparietal cortex, lateral cerebellum, hypothalamus, and a region that includes the anterior temporal cortex, amygdala, and hippocampal formation, suggesting that these regions participate in the emotional response to certain exteroceptive sensory stimuli. Recall-generated sadness was associated with significantly greater increases in activity in the vicinity of the anterior insular cortex, suggesting that this region participates in the emotional response to potentially distressing cognitive or interoceptive sensory stimuli.ConclusionsWhile this study should be considered preliminary, it identified brain regions that participate in externally and internally generated human emotion.