A new diarylheptanoid from Alpinia officinarum promotes the differentiation of 3T3-L1 preadipocytes
A new diarylheptanoid from Alpinia officinarum promotes the differentiation of 3T3-L1 preadipocytes
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DOI：
10.1080/14786419.2017.1327858
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发表时间：
2018-03
影响因子：
2.2
通讯作者：
Xuguang Zhang;Xiaopo Zhang;Yong Wang;F. Chen;Youbin Li;Yonghui Li;Yinfeng Tan;Jingwen Gong
中科院分区：
文献类型：
--
作者：
Xuguang Zhang;Xiaopo Zhang;Yong Wang;F. Chen;Youbin Li;Yonghui Li;Yinfeng Tan;Jingwen Gong
本文报道了一种新的二芳基庚烷类化合物，即反式-（4 R，5S）-环氧-1，7-二苯基-3-庚酮（1）和一种新的天然产物7-从高良姜（Alpinia officinarum Hance）的水提物中分离得到4-（4″-羟基-3 ″-甲氧基苯基）-1-苯基-庚-4E，6 E-二烯-3-酮（2），7-二苯基-4E-烯-3-庚酮（4）和5-甲氧基-1，7-二苯基-3-庚酮（5）。主要通过IR、NMR和HRMS等物理数据对化合物的结构进行了表征。这项研究强调了1中的4，5-环氧基部分在二芳基庚烷类化合物中很少见到。此外，测试了五个分离物的3 T3-L1前脂肪细胞的分化活性。结果表明，这些化合物均能剂量依赖性地促进脂肪细胞分化，且无细胞毒性（IC 50> 100 μM）。
Abstract A new diarylheptanoid, namely trans-(4R,5S)-epoxy-1,7-diphenyl-3-heptanone (1), and a new natural product, 7-(4″-hydroxy-3″-methoxyphenyl)-1-phenyl-hepta-4E,6E-dien-3-one (2), were obtained from the aqueous extract of Alpinia officinarum Hance, together with three other diarylheptanoids, 5-hydroxy-1,7-diphenyl-3-heptanone (3), 1,7-diphenyl-4E-en-3-heptanone (4) and 5-methoxy-1,7-diphenyl-3-heptanone (5). The structures were characterised mainly by analysing their physical data including IR, NMR and HRMS. This study highlights that the 4,5-epoxy moiety in 1 is rarely seen in diarylheptanoids. In addition, the five isolates were tested for their differentiation activity of 3T3-L1 preadipocytes. The results showed that these compounds could dose-dependently promote adipocyte differentiation without cytotoxicity (IC50 > 100 μM).