Serum Uric Acid and Risk of CKD in Type 2 Diabetes
Serum Uric Acid and Risk of CKD in Type 2 Diabetes
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DOI：
10.2215/cjn.03140315
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发表时间：
2015-11-01
影响因子：
9.8
通讯作者：
Pontremoli, Roberto
中科院分区：
文献类型：
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作者：
De Cosmo, Salvatore;Viazzi, Francesca;Pontremoli, Roberto
背景与目的血尿酸可预测肾脏疾病的发生和进展，但血尿酸是否为糖尿病肾病的独立危险因素尚不清楚。我们的目的是研究尿酸水平和慢性肾脏病的发展之间的关系，在2型diabetes.Design，设置，参与者和测量2型糖尿病患者队列的纵向研究，从意大利临床糖尿病网络协会的数据库。从2004年1月1日至2008年6月30日期间在糖尿病中心就诊的62，830例患者中，我们考虑了基线eGFR值>= 60 ml/min/1.73 m2且白蛋白排泄正常的患者（n= 20，142）。13,964例患者的尿白蛋白排泄、GFR和血尿酸可用。我们通过调整潜在混杂因素的多项逻辑回归模型评估血清尿酸五分位数与CKD组分发生的相关性。我们计算了eGFR的相对风险比（RRRs），
Background and objective Serum uric acid may predict the onset and progression of kidney disease, but it is unclear whether uric acid is an independent risk factor for diabetic nephropathy. Our aim was to study the relationship between uric acid levels and the development of CKD components in patients with type 2 diabetes.Design, setting, participants, & measurements Longitudinal study of a cohort of patients with type 2 diabetes from the database of the Italian Association of Clinical Diabetologists network. From a total of 62,830 patients attending the diabetes centers between January 1, 2004, and June 30, 2008, we considered those with baseline eGFR values >= 60 ml/min per 1.73 m(2) and normal albumin excretion (n=20,142). Urinary albumin excretion, GFR, and serum uric acid were available in 13,964 patients. We assessed the association of serum uric acid quintiles with onset of CKD components by multinomial logistic regression model adjusting for potential confounders. We calculated the relative risk ratios (RRRs) for eGFR