Controlling Synfire Chain by Inhibitory Synaptic Input
Controlling Synfire Chain by Inhibitory Synaptic Input
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DOI：
10.1143/jpsj.76.044806
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发表时间：
2007-04
影响因子：
1.7
通讯作者：
T. Shinozaki;Hideyuki Câteau;H. Urakubo;M. Okada
中科院分区：
文献类型：
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作者：
T. Shinozaki;Hideyuki Câteau;H. Urakubo;M. Okada
在神经元网络中的高度同步放电的传播，称为synfire链，已经在理论和实验上进行了积极的研究。的时间精度和显着的稳定性的传播已在以前的研究中反复检查。然而，为了使这种信号转导模式在大脑中处理信息中发挥重要作用，还应该动态和灵活地控制传播。在这里，我们表明，抑制性而非兴奋性输入可以双向调节传播，即，根据输入的定时来增强或抑制同步触发。我们基于Hodgkin-Huxley神经元模型的模拟证明了这种双向调制，并表明它应该通过任何生物启发的建模来实现。我们的发现可能有助于描述一个具体的场景，即如何适当地控制位于神经元网络中的多个synfire链来执行重要的信息处理。
The propagation of highly synchronous firings across neuronal networks, called the synfire chain, has been actively studied both theoretically and experimentally. The temporal accuracy and remarkable stability of the propagation have been repeatedly examined in previous studies. However, for such a mode of signal transduction to play a major role in processing information in the brain, the propagation should also be controlled dynamically and flexibly. Here, we show that inhibitory but not excitatory input can bidirectionally modulate the propagation, i.e., enhance or suppress the synchronous firings depending on the timing of the input. Our simulations based on the Hodgkin–Huxley neuron model demonstrate this bidirectional modulation and suggest that it should be achieved with any biologically inspired modeling. Our finding may help describe a concrete scenario of how multiple synfire chains lying in a neuronal network are appropriately controlled to perform significant information processing.