Oral microflora and selection of resistance after a single dose of amoxicillin
Oral microflora and selection of resistance after a single dose of amoxicillin
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DOI：
10.1016/j.cmi.2016.08.008
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发表时间：
2016-11-01
影响因子：
14.2
通讯作者：
Lund, B.
中科院分区：
文献类型：
--
作者：
Khalil, D.;Hultin, M.;Lund, B.
这项研究旨在确定单剂量抗生素预防对正常口腔微生物区系的影响。29名健康志愿者单次服用2g阿莫西林。分别于给药前(第1天)、第2、5、10、17、24天采集唾液，进行细菌培养和药敏分析。在使用抗生素之前，21%(6/29)的人携带青霉素-V和阿莫西林耐药绿色链球菌。阿莫西林单次给药后第2天和第5天唾液链球菌显著减少，第2天其他绿色链球菌显著减少，第2天和第5天阿莫西林敏感性降低的绿色链球菌比例显著增加。单次阿莫西林可引起口腔微生物生态紊乱，诱导耐药菌株的选择。D.Khalil，CMI 2016；22：949.e1-949.e4(C)2016欧洲临床微生物学和传染病学会。爱思唯尔有限公司出版。保留所有权利。
The study aimed to determine the effects of a single-dose antibiotic prophylaxis on normal oral microflora. A single dose of 2 g amoxicillinwas given to 29 healthy volunteers. Saliva was collected before antibiotic administration (day 1), and again on days 2, 5, 10, 17 and 24 and subjected to culturing and antibiotic sensitivity analysis. Twenty-one per cent (6/29) of the individuals carried penicillin-V-and amoxicillin-resistant viridans streptococci before antibiotic administration. After a single dose of amoxicillin there was a significant reduction in Streptococcus salivarius on days 2 and 5, a significant reduction in other viridans streptococci on day 2 and the proportion of viridans streptococci with reduced susceptibility to amoxicillin was significantly increased on days 2 and 5. A single dose of amoxicillin can cause an ecological disturbance and induce selection of resistant strains in the oral microflora. D. Khalil, CMI 2016;22:949.e1-949.e4 (C) 2016 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.