The validity of a rheumatoid arthritis medical records-based index of severity compared with the DAS28
The validity of a rheumatoid arthritis medical records-based index of severity compared with the DAS28
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DOI：
10.1186/ar1921
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发表时间：
2006-01-01
影响因子：
4.9
通讯作者：
Solomon, Daniel H.
中科院分区：
文献类型：
--
作者：
Sato, Masayo;Schneeweiss, Sebastian;Solomon, Daniel H.
这项工作的目的是评估收敛的有效性，以前开发的类风湿性关节炎的医疗记录为基础的严重程度指数（RARBIS），通过比较它与28关节疾病活动度评分（DAS 28）。本研究在Brigham and Women's Hospital风湿性关节炎序贯研究（BRASS）的受试者中进行。我们从BRASS中选择了100例类风湿性关节炎（RA）患者，DAS 28评分平均分布在四个四分位数中。审查病历以计算RARBIS，包括以下类别的指标：既往手术史、放射学和实验室检查结果、临床和功能状态以及关节外表现。在总研究人群和相关亚组中评估了RARBIS和DAS之间的斯皮尔曼相关性28。我们对分量表进行了重新加权，并重新计算了RARBIS评分。这是基于DAS 28和子量表之间的相关性结果进行的;以及DAS 28（作为因变量）和5个子量表（作为自变量）的多元线性回归结果。平均RARBIS为4.36（范围0 - 11）。在总研究队列中，RARBIS与DAS 28中度相关（r = 0.41，95%置信区间[CI] 0.23 - 0.56）。在亚组分析中，包括年龄、性别、类风湿因子状态和疾病持续时间，我们发现相关性没有统计学显著差异。重新加权后，RARBIS与DAS 28之间的相关性有所改善（r = 0.48，95% CI 0.31 - 0.62）。总之，在该人群中，RARBIS与DAS 28中度相关。RARBIS对类风湿关节炎患者及其相关亚组具有表面效度和聚合效度，可用于类风湿关节炎患者的病历研究。
The objective of this work was to assess the convergent validity of a previously developed rheumatoid arthritis medical records-based index of severity (RARBIS) by comparing it with the 28-joint Disease Activity Score (DAS28). This study was conducted in subjects within the Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study ( BRASS). We selected 100 patients with rheumatoid arthritis ( RA) from the BRASS with DAS28 scores equally distributed in four quartiles. The medical records were reviewed to calculate the RARBIS, which includes indicators from the following categories: prior surgical history, radiologic and laboratory findings, clinical and functional status, and extra-articular manifestations. The Spearman correlation between the RARBIS and the DAS28 was assessed in the total study population and in relevant subgroups. We re-weighted on subscales and recalculated the RARBIS score. This was performed based on findings of correlations between the DAS28 and subscales; and also the result from a multiple linear regression with the DAS28 ( as a dependent variable) and five subscales ( as independent variables). The mean RARBIS was 4.36 ( range 0 - 11). Among the total study cohort, the RARBIS was moderately correlated with the DAS28 ( r = 0.41, 95% confidence interval [CI] 0.23 - 0.56). In subgroup analyses, including age, gender, rheumatoid factor status, and disease duration, we found no statistically significant differences in the correlations. After re-weighting, the correlation between the RARBIS and the DAS28 was somewhat improved ( r = 0.48, 95% CI 0.31 - 0.62). In conclusion, the RARBIS correlated moderately well with the DAS28 in this population. The RARBIS has both face and convergent validity for patients with RA and relevant subgroups and may have application for medical records studies in patients with RA.