Quantification of calcification in atherosclerotic lesions
Quantification of calcification in atherosclerotic lesions
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DOI：
10.1161/01.atv.0000172017.79441.73
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发表时间：
2005-08-01
影响因子：
8.7
通讯作者：
Morrisett, JD
中科院分区：
文献类型：
--
作者：
Higgins, CL;Marvel, SA;Morrisett, JD
钙化可以几种形式的磷酸钙沉积在整个血管系统，包括羟基磷灰石(CHA)。矿化导致的动脉内钙蓄积和骨质疏松引起的骨钙流失往往并存，血管钙化可能与骨重塑有着共同的机制。瓣膜和动脉中钙化的沉积降低了瓣膜或动脉壁的弹性，这是动脉瘤和狭窄的主要原因。钙化和其他成分造成的动脉阻塞可能会导致心脏病发作和中风。股动脉的矿化可导致腿部间歇性跛行，导致行动不便。准确的钙化测量对于确定与这一过程相关的其他因素并最终阐明钙化的机制(S)至关重要。有多种方法可用于体内诊断和治疗的可视化和测量钙化，以及研究体外钙化过程。这篇综述对旧的已建立的钙化方法和新发展的钙化技术进行了关键的比较。
Calcification can be deposited throughout the vasculature in several forms of calcium phosphate, including calcium hydroxyapatite (CHA). Calcium accumulation in arteries by mineralization and calcium loss from bone by osteoporosis often coexist, and vascular calcification may share common mechanisms with bone remodeling. Deposition of calcification in valves and arteries diminishes the valvular or arterial wall elasticity, a major cause of aneurysm and stenosis. Obstruction of arteries by calcification and other components can lead to heart attack and stroke. Mineralization in the femoral arteries can cause intermittent claudication in the legs, causing decreased mobility. Accurate measurement of calcification is essential for identifying other factors associated with this process and ultimately for elucidating the mechanism(s) of calcification. A wide range of methods for visualizing and measuring calcification for diagnosis and treatment in vivo and for studying the calcification process ex vivo are available. This review provides a critical comparison of older established methods and newer evolving technologies for quantifying calcification.