ABNORMAL SEX STEROID-SECRETION AND BINDING IN MASSIVELY OBESE WOMEN
ABNORMAL SEX STEROID-SECRETION AND BINDING IN MASSIVELY OBESE WOMEN
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DOI：
10.1111/j.1365-2265.1980.tb02721.x
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发表时间：
1980-01-01
影响因子：
3.2
通讯作者：
JEFFCOATE, SL
中科院分区：
文献类型：
--
作者：
KOPELMAN, PG;PILKINGTON, TRE;JEFFCOATE, SL
研究人员测量了 23 名严重肥胖女性和 10 名年龄匹配的瘦女性志愿者的血浆性类固醇和性激素结合球蛋白 (SHBG) 浓度。在肥胖女性中，血浆睾酮浓度增加（肥胖 3.2 .+-. 0.5 nM，对照 1.7 .+-. 0.5 nM，P < 0.3）和雄烯二酮浓度（肥胖 9.7 .+-. 1.2 nM，对照 4.4 .+-. 0.6 nM，P = < 0.01），雌酮：雌二醇的比率增加（肥胖 2.4 .+-. 0.4，对照 1.0 .+-. 0.1，P = < 0.1）和 SHBG 水平降低（肥胖 30 .+-. 4 nM，对照 60 .+-. 8 nM，P = < 0.001）。肥胖与多囊卵巢综合征（其中性类固醇浓度和结合的变化模式相似）不同，肥胖与血清黄体生成素 (LH) 卵泡刺激素 (FSH) 水平的正常增加有关，这是对 LHRH [LH 释放激素] 的反应。肥胖者常见的月经异常是由于性类固醇的分泌和结合异常造成的。此外，在存在此类变化的情况下，LH 和 FSH 的分泌未改变是下丘脑功能紊乱的证据。
The plasma concentrations of sex steroids and sex hormone-binding globulin (SHBG) were measured in 23 massively obese women and 10 age-matched lean female volunteers. In the obese women increased plasma testosterone (obese 3.2 .+-. 0.5 nM controls 1.7 .+-. 0.5 nM, P < 0.3) and androstenedione concentrations (obese 9.7 .+-. 1.2 nM, controls 4.4 .+-. 0.6 nM, P = < 0.01) an increased ratio of estrone:estradiol (obese 2.4 .+-. 0.4, controls 1.0 .+-. 0.1, P = < 0.1) and decreased SHBG levels (obese 30 .+-. 4 nM, controls 60 .+-. 8 nM, P = < 0.001) were found. Obesity differed from the polycystic ovary syndrome (in which a similar pattern of changes of sex steroid concentrations and binding are seen) in that it was associated with normal increases in serum luteinizing hormone (LH) follicle stimulating hormone (FSH) levels in response to the administration of LHRH [LH releasing hormone]. The common occurrence of menstrual abnormalities in obesity results from abnormal secretion and binding of sex steroids. In addition, the unaltered secretion of LH and FSH in the presence of such changes is evidence for a disorder of hypothalamic function.