Analysis of Fusobacterium nucleatum and Streptococcus gallolyticus in saliva of colorectal cancer patients
Analysis of Fusobacterium nucleatum and Streptococcus gallolyticus in saliva of colorectal cancer patients
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DOI：
10.2217/bmm-2019-0020
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发表时间：
2019-06-01
影响因子：
2.2
通讯作者：
Yalcin, Suayib
中科院分区：
文献类型：
--
作者：
Guven, Deniz Can;Dizdar, Omer;Yalcin, Suayib
本研究的目的是检测结直肠癌（CRC）患者和对照组唾液中核梭菌（Fn）、牙龈卟啉单胞菌（Pg）和溶食链球菌（Sg）的患病率和数量。方法：对71例结直肠癌患者和77例对照组进行PCR分析。结果：患者唾液样本中Fn （p = 0.001）和Sg （p < 0.001）含量高于对照组。微卫星不稳定（+）组Fn、Sg含量较低。通过受试者工作特征分析评估唾液Sg量对CRC有诊断价值（AUC: 0.84, 95% CI: 0.72-0.96）。结论：结直肠癌患者唾液中Fn和Sg含量较高。唾液Sg有助于区分结直肠癌。
The aim of the study was to examine the prevalence and amount of Fusobacterium nucleatum (Fn), Porphyromonas gingivalis (Pg) and Streptococcus gallolyticus (Sg) in the saliva of colorectal cancer (CRC) patients and controls. Methods: PCR analyses performed in 71 CRC patients and 77 controls. Results: Saliva samples of patients had higher amounts of Fn (p = 0.001) and Sg (p < 0.001) compared with controls. Amount of Fn and Sg were lower in the microsatellite instability (+) group. Evaluation of salivary Sg amount by receiver operating characteristics analysis found to have diagnostic value for CRC (AUC: 0.84, 95% CI: 0.72-0.96). Conclusion: We found higher amounts of Fn and Sg in the saliva of CRC patients. Salivary Sg could helpful in distinction of CRC.