Conservation and diversification of three-repeat Myb transcription factors in plants
Conservation and diversification of three-repeat Myb transcription factors in plants
复制标题
DOI：
10.1007/s10265-005-0192-8
复制
发表时间：
2005-02-01
影响因子：
2.8
通讯作者：
Ito, M
中科院分区：
文献类型：
--
作者：
Ito, M
Myb转录因子家族的特点是存在一个保守的dna结合结构域，称为Myb结构域，它通常包含两个或三个不完全重复序列。在这个家族中，含有三个重复基序的Myb蛋白在进化上是保守的，在细胞周期中起重要作用。脊椎动物有三种Myb蛋白，c-Myb， a -Myb和B-Myb，它们都包含三个重复序列，并被认为在G1/S转变中起作用。在植物中，具有3个重复序列的Myb蛋白是由Myb基因大家族中的一个小亚家族中的基因编码的，大多数基因编码只有2个重复序列的Myb蛋白。我们已经证明，具有三个重复的Myb蛋白在烟草的G2/M中具有重要作用，通过调节细胞周期蛋白B基因和许多其他基因的转录，这些基因在细胞周期的相似时间表达。本文综述了植物Myb三重复基因的结构、功能和调控方面的研究进展，并讨论了它们与动物Myb三重复基因的保守性和差异性。
The Myb family of transcription factors is characterized by the presence of a conserved DNA-binding domain called the Myb domain, which typically contains two or three imperfect repeat sequences. Within this family, Myb proteins containing three repeat motifs are evolutionarily conserved and have important roles in the cell cycle. Vertebrates have three Myb proteins, c-Myb, A-Myb, and B-Myb, all of which contain three repeats and are proposed to have a role at the G1/S transition. In plants, Myb proteins with three repeats are encoded by genes in a small subfamily within the large Myb gene family, most of which encode for Myb proteins with only two repeats. We have shown that Myb proteins with three repeats have an important role at the G2/M in tobacco, by regulating transcription of cyclin B genes and many other genes that are expressed at a similar time in the cell cycle. In this review, we summarize current knowledge on structure, function, and regulation of the plant Myb factors with three repeats, and discuss their conserved and divergent features in comparison with animal counterparts.