Regeneration of Hypoglossal Nerve Axons Following Blockade of the Axotomy‐induced Microglial Cell Reaction in the Rat
Regeneration of Hypoglossal Nerve Axons Following Blockade of the Axotomy‐induced Microglial Cell Reaction in the Rat
复制标题
阻断大鼠轴突切开术诱导的小胶质细胞反应后舌下神经轴突的再生
DOI：
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发表时间：
1993
影响因子：
3.4
通讯作者：
H. Aldskogius
中科院分区：
文献类型：
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作者：
M. Svensson;H. Aldskogius
本研究的目的是检查是否抑制周围的小胶质细胞反应轴突切断运动神经元影响随后的再生过程中受伤的轴突。通过向脑室系统输注阿糖胞苷（ARA‐C）阻断大鼠舌下神经核中的小胶质细胞反应。轴突再生进行了评估，确定在一个确定的水平远端的压碎网站，神经元的数量，可以逆行标记从远端残端以及运动终板在舌头在不同的时间损伤后的数量的有髓轴突的数量和大小分布。在ARA‐C‐给药和未给药动物之间未观察到任何这些参数的显著差异。因此，可以得出结论，小胶质细胞反应是不必要的周围神经再生和恢复目标接触在正常的速度和正常的程度。
The aim of the present study was to examine whether inhibition of the microglial cell reaction around axotomized motoneurons affects the subsequent regeneration process of the injured axons. The microglial cell reaction in the hypoglossal nucleus of the rat was blocked by infusion of cytosine‐arabinoside (ARA‐C) into the ventricular system. Axon regeneration was evaluated by determining the number and size distribution of myelinated axons at a defined level distal to the crush site, the number of neurons which could be retrogradely labelled from the distal stump as well as the number of motor endplates in the tongue at various times following injury. No significant difference was observed for any of these parameters between ARA‐C‐treated and untreated animals. Therefore, it is concluded that the microglial cell reaction is not necessary for peripheral nerves to regenerate and restore target contact at a normal rate and to a normal extent.