Functional interactions between stress and the endocannabinoid system: from synaptic signaling to behavioral output.
Functional interactions between stress and the endocannabinoid system: from synaptic signaling to behavioral output.
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DOI：
10.1523/jneurosci.4283-10.2010
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发表时间：
2010-11-10
期刊：
影响因子：
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通讯作者：
Bains JS
中科院分区：
文献类型：
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作者：
Hill MN;Patel S;Campolongo P;Tasker JG;Wotjak CT;Bains JS
内源性大麻素信号分布于大脑各处，调节兴奋性和抑制性神经递质的突触释放。在下丘脑的应激敏感核团以及杏仁核等上游边缘结构中存在内源性大麻素信号，这表明它可能在调节应激的神经内分泌和行为效应方面发挥重要作用。本文综述的证据表明，内源性大麻素信号参与激活和终止下丘脑-垂体-肾上腺(HPA)轴对急性和重复应激的反应。然而，除了神经内分泌功能外，应激和糖皮质激素也招募内源性大麻素信号来调节认知和情绪过程，如记忆巩固和消退。总而言之，这些数据证明了内源性大麻素信号在多个水平上作为应激反应的调节器和效应器的重要性。
Endocannabinoid signalling is distributed throughout the brain, regulating synaptic release of both excitatory and inhibitory neurotransmitters. The presence of endocannabinoid signalling within stress-sensitive nuclei of the hypothalamus, as well as upstream limbic structures such as the amygdala, suggests it may play an important role in regulating the neuroendocrine and behavioral effects of stress. The evidence reviewed here demonstrates that endocannabinoid signalling is involved in both activating and terminating the hypothalamic-pituitary-adrenal (HPA) axis response to both acute and repeated stress. In addition to neuroendocrine function, however, endocannabinoid signalling is also recruited by stress and glucocorticoid hormones to modulate cognitive and emotional processes such as memory consolidation and extinction. Collectively, these data demonstrate the importance of endocannabinoid signalling at multiple levels as both a regulator and effector of the stress response.